PDF(Pubmed)
Abstract：
OBJECTIVE: Are embryo culture conditions, including type of incubator, oxygen tension, and culture media, associated with obstetric or neonatal complications following in vitro fertilization (IVF)?
METHODS: A systematic search of MEDLINE, EMBASE, and Cochrane Library was performed from January 01, 2008, until October 31, 2021. The studies reporting quantitative data on at least one of the primary outcomes (birthweight and preterm birth) for the exposure group and the control group were included. For oxygen tension, independent meta-analysis was performed using Review Manager, comparing hypoxia/normoxia. For culture media, a network meta-analysis was carried out using R software, allowing the inclusion of articles comparing two or more culture media.
RESULTS: After reviewing 182 records, 39 full-text articles were assessed for eligibility. A total of 28 studies were kept for review. Meta-analysis about the impact of incubator type on perinatal outcomes could not be carried out because of a limited number of studies. For oxygen tension, three studies were included. The pairwise meta-analysis comparing hypoxia/normoxia did not show any statistical difference for birthweight and gestational age at birth. For culture media, 18 studies were included. The network meta-analysis failed to reveal any significant impact of different culture media on birthweight or preterm birth.
CONCLUSIONS: No difference was observed for neonatal outcomes according to the embryo culture conditions evaluated in this review. Further research is needed about the safety of IVF culture conditions as far as future children\'s health is concerned.
METHODS: A systematic search of MEDLINE, EMBASE, and Cochrane Library was performed from January 01, 2008, until October 31, 2021. The studies reporting quantitative data on at least one of the primary outcomes (birthweight and preterm birth) for the exposure group and the control group were included. For oxygen tension, independent meta-analysis was performed using Review Manager, comparing hypoxia/normoxia. For culture media, a network meta-analysis was carried out using R software, allowing the inclusion of articles comparing two or more culture media.
RESULTS: After reviewing 182 records, 39 full-text articles were assessed for eligibility. A total of 28 studies were kept for review. Meta-analysis about the impact of incubator type on perinatal outcomes could not be carried out because of a limited number of studies. For oxygen tension, three studies were included. The pairwise meta-analysis comparing hypoxia/normoxia did not show any statistical difference for birthweight and gestational age at birth. For culture media, 18 studies were included. The network meta-analysis failed to reveal any significant impact of different culture media on birthweight or preterm birth.
CONCLUSIONS: No difference was observed for neonatal outcomes according to the embryo culture conditions evaluated in this review. Further research is needed about the safety of IVF culture conditions as far as future children\'s health is concerned.
摘要：
目的：是胚胎培养条件，包括孵化器的类型，氧张力,和文化媒介，与体外受精（IVF）后产科或新生儿并发症有关？
方法：系统搜索MEDLINE，EMBASE,Cochrane图书馆于2008年1月1日至2021年10月31日进行。研究报告了暴露组和对照组的至少一个主要结局（出生体重和早产）的定量数据。对于氧气张力，使用ReviewManager进行独立荟萃分析，比较缺氧/常氧。对于文化媒介，使用R软件进行网络荟萃分析，允许包含比较两种或多种培养基的文章。
结果：查看182条记录后，对39篇全文文章进行了资格评估。共有28项研究进行审查。由于研究数量有限，无法进行有关孵化器类型对围产期结局影响的荟萃分析。对于氧气张力，包括三项研究。比较缺氧/常氧的成对荟萃分析未显示出生体重和出生时胎龄的任何统计学差异。对于文化媒介，共纳入18项研究。网络荟萃分析未能揭示不同培养基对出生体重或早产的任何重大影响。
结论：根据本综述评估的胚胎培养条件，新生儿结局没有差异。就未来儿童的健康而言，需要进一步研究IVF培养条件的安全性。
方法：系统搜索MEDLINE，EMBASE,Cochrane图书馆于2008年1月1日至2021年10月31日进行。研究报告了暴露组和对照组的至少一个主要结局（出生体重和早产）的定量数据。对于氧气张力，使用ReviewManager进行独立荟萃分析，比较缺氧/常氧。对于文化媒介，使用R软件进行网络荟萃分析，允许包含比较两种或多种培养基的文章。
结果：查看182条记录后，对39篇全文文章进行了资格评估。共有28项研究进行审查。由于研究数量有限，无法进行有关孵化器类型对围产期结局影响的荟萃分析。对于氧气张力，包括三项研究。比较缺氧/常氧的成对荟萃分析未显示出生体重和出生时胎龄的任何统计学差异。对于文化媒介，共纳入18项研究。网络荟萃分析未能揭示不同培养基对出生体重或早产的任何重大影响。
结论：根据本综述评估的胚胎培养条件，新生儿结局没有差异。就未来儿童的健康而言，需要进一步研究IVF培养条件的安全性。
