PDF(Pubmed)
Abstract：
Luteinizing hormone (LH) is present throughout the natural follicular phase. However, the debate is still not settled on whether LH is needed during ovarian stimulation in IVF. This commentary looks at the evolution of this debate, mentioning three elephants in the room that were ignored by the Pharma industry, professional organizations, and clinicians alike: 1. The different endocrinology between the long agonist and the antagonist protocols. 2. The fixed dose of the two most widely commercially available antagonist preparations, namely cetrorelix and ganirelix. 3. The fact that most research in this area uses population-based criteria, ignoring endocrine parameters. Individual genetics of the LH receptor gene may also serve to individualize LH needs during stimulation; however, the jury is still out regarding this approach. CONCLUSIONS: Individual endocrine and genetics parameters may shed meaningful light on the question of LH supplemental during ovarian stimulation.
摘要：
促黄体生成素(LH)存在于整个自然卵泡期。然而,关于IVF中卵巢刺激期间是否需要LH的争论仍未解决.这篇评论着眼于这场辩论的演变，提到房间里被制药行业忽视的三只大象，专业组织,和临床医生一样：1。长激动剂和拮抗剂方案之间的不同内分泌学。2.两种市售最广泛的拮抗剂制剂的固定剂量，即cetrorelix和ganirelix.3.事实上，该领域的大多数研究都使用基于人口的标准，忽略内分泌参数。LH受体基因的个体遗传学也可能有助于在刺激期间个性化LH需求;然而，关于这种方法，陪审团仍然没有意见。结论：个体内分泌和遗传学参数可能对卵巢刺激期间补充LH的问题有意义。
