Abstract：
Rosacea is a common chronic skin disease distributed primarily around the central face. Ocular manifestations of rosacea are poorly studied, and estimates of prevalence vary widely, ranging from 6% to 72% in the rosacea population. Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin A derivatives, and intense pulsed light; however, a direct comparison of treatment methods for ocular rosacea is lacking. This review aims to compare treatment efficacy and adverse events for different treatment modalities in ocular rosacea. We performed a systematic review by searching Cochrane, MEDLINE and Embase. Title, abstract, full text screening, and data extraction were done in duplicate. Sixty-six articles met the inclusion criteria, representing a total of 1,275 patients. The most effective treatment modalities were topical antimicrobials and oral antibiotics, which achieved complete or partial response in 91% (n = 82/90) and 89% (n = 525/580) of patients respectively, followed by intense pulsed light (89%, n = 97/109 partial response), cyclosporine ophthalmic emulsion (87% n = 40/46), and lid hygiene (65%, n = 67/105). Combination treatments achieved a complete or partial response in 90% (n = 69/77). Results suggest that topical antimicrobials, oral antibiotics, intense pulsed light. and cyclosporine were the most efficacious single modality treatments.
摘要：
酒渣鼻是一种常见的慢性皮肤病，主要分布在中央面部。酒渣鼻的眼部表现研究甚少，对患病率的估计差异很大，酒渣鼻人群中的6%到72%不等。眼部酒渣鼻的治疗选择包括眼睑卫生，局部和口服抗生素，环孢菌素眼用乳剂,口服维生素A衍生物，和强烈的脉冲光；然而，缺乏对眼部酒渣鼻治疗方法的直接比较。本文旨在比较不同治疗方式对眼部酒渣鼻的治疗效果和不良事件。我们通过搜索Cochrane进行了系统的审查，MEDLINE和Embase。Title,abstract,全文筛选,和数据提取一式两份。六十六条符合纳入标准，代表总共1,275名患者。最有效的治疗方式是局部抗菌药物和口服抗生素，分别在91％（n=82/90）和89％（n=525/580）的患者中获得完全或部分缓解，其次是强脉冲光(89%，n=97/109部分响应)，环孢素眼用乳剂（87%n=40/46），和盖子卫生(65%，n=67/105)。联合治疗实现了90%的完全或部分反应(n=69/77)。结果表明，局部抗菌药物，口服抗生素,强烈的脉冲光。和环孢素是最有效的单一模式治疗。
