PDF(Pubmed)
Abstract：
Chronic cough is common, negatively affects quality of life and has limited treatment options. Inhibition of purinergic signalling is a promising therapeutic approach but is associated with taste-related adverse effects. Little is known about treatment preferences from the perspective of patients with chronic cough, such as trade-offs between efficacy and side effect.
Patients with chronic cough completed an online discrete choice experiment survey in which they answered a series of questions requiring a choice between two constructed treatment options characterised by varying attribute levels. Selection of cough and taste-related attributes was informed by qualitative interviews and clinical trial data. Logit-based models were used to analyse resulting choice data.
The discrete choice experiment survey was completed by 472 participants with chronic cough. Among study attributes, frequency of intense cough attacks was the most important to participants, followed by taste change, frequency of night-time coughing and frequency of daytime coughing. To accept the least preferred taste disturbance of a bitter, metallic, chalky or oily taste change, participants required either: (1) elimination of night-time cough along with a slight reduction in daytime cough; (2) elimination of daytime cough along with a pronounced reduction in night-time or (3) reduction in intense cough attacks from 7 to 2 times per week. Two distinct preference patterns were identified, each placing different importance on efficacy versus side effect trade-offs.
Participants with chronic cough were willing to accept some taste disturbances in exchange for improved efficacy of chronic cough treatments. Knowledge of patient preferences can facilitate shared decision-making.
Patients with chronic cough completed an online discrete choice experiment survey in which they answered a series of questions requiring a choice between two constructed treatment options characterised by varying attribute levels. Selection of cough and taste-related attributes was informed by qualitative interviews and clinical trial data. Logit-based models were used to analyse resulting choice data.
The discrete choice experiment survey was completed by 472 participants with chronic cough. Among study attributes, frequency of intense cough attacks was the most important to participants, followed by taste change, frequency of night-time coughing and frequency of daytime coughing. To accept the least preferred taste disturbance of a bitter, metallic, chalky or oily taste change, participants required either: (1) elimination of night-time cough along with a slight reduction in daytime cough; (2) elimination of daytime cough along with a pronounced reduction in night-time or (3) reduction in intense cough attacks from 7 to 2 times per week. Two distinct preference patterns were identified, each placing different importance on efficacy versus side effect trade-offs.
Participants with chronic cough were willing to accept some taste disturbances in exchange for improved efficacy of chronic cough treatments. Knowledge of patient preferences can facilitate shared decision-making.
摘要：
背景：慢性咳嗽很常见，负面影响生活质量，治疗选择有限。嘌呤能信号的抑制是一种有前途的治疗方法，但与味觉相关的不良反应有关。从慢性咳嗽患者的角度来看，对治疗偏好知之甚少，如疗效和副作用之间的权衡。
方法：慢性咳嗽患者完成了一项在线离散选择实验调查，其中他们回答了一系列问题，需要在两种具有不同属性水平的构建治疗方案之间进行选择。定性访谈和临床试验数据告知咳嗽和味觉相关属性的选择。基于Logit的模型用于分析产生的选择数据。
结果：离散选择实验调查由472名患有慢性咳嗽的参与者完成。在研究属性中，强烈咳嗽发作的频率对参与者来说是最重要的，随之而来的是味道的变化，夜间咳嗽的频率和白天咳嗽的频率。要接受苦味中最不喜欢的味道干扰，金属,白垩或油腻的味道改变，参与者要求:(1)消除夜间咳嗽,同时轻微减少日间咳嗽;(2)消除日间咳嗽,同时显著减少夜间咳嗽;(3)减少剧烈咳嗽发作,每周7~2次.确定了两种不同的偏好模式，每个人对疗效和副作用权衡的重要性都不同。
结论：慢性咳嗽患者愿意接受一些味觉紊乱，以换取慢性咳嗽治疗的疗效提高。了解患者偏好可以促进共同决策。
方法：慢性咳嗽患者完成了一项在线离散选择实验调查，其中他们回答了一系列问题，需要在两种具有不同属性水平的构建治疗方案之间进行选择。定性访谈和临床试验数据告知咳嗽和味觉相关属性的选择。基于Logit的模型用于分析产生的选择数据。
结果：离散选择实验调查由472名患有慢性咳嗽的参与者完成。在研究属性中，强烈咳嗽发作的频率对参与者来说是最重要的，随之而来的是味道的变化，夜间咳嗽的频率和白天咳嗽的频率。要接受苦味中最不喜欢的味道干扰，金属,白垩或油腻的味道改变，参与者要求:(1)消除夜间咳嗽,同时轻微减少日间咳嗽;(2)消除日间咳嗽,同时显著减少夜间咳嗽;(3)减少剧烈咳嗽发作,每周7~2次.确定了两种不同的偏好模式，每个人对疗效和副作用权衡的重要性都不同。
结论：慢性咳嗽患者愿意接受一些味觉紊乱，以换取慢性咳嗽治疗的疗效提高。了解患者偏好可以促进共同决策。
