Abstract:
Lead-203 is a SPECT emitter that can be used in theranostic applications as an imaging counterpart of lead-212 which is intended to be used for alpha therapy as lead-212/bismuth-212 in-vivo generator. In our study, we explore the production of lead-203 using enriched thallium-205 target irradiated by a deuteron beam. Excitation functions of deuteron induced reactions leading to the formation of 204m,203m2+m1+g,202m,201m+gPb, 202Tl and 203m+gHg isotopes were determined experimentally in the energy range from 21 MeV to 34 MeV. Cross sections were measured using the stacked foils technique and a set of two monitor foils, natNi and natTi for beam intensity evaluation. The experimental excitation functions of the investigated reactions were compared with the published data and also with the TENDL-2021 nuclear database. From our experimental data, we calculated lead-203 thick target yield in the energy range between 30 MeV and 32.5 MeV to be 56.7 MBq/μAh ±6.1 MBq/μAh. This value is compatible with large batch production showing that deuteron beams can be used for a routine production process. However, special attention must be paid to 203Hg and other lead contaminants.
摘要:
Lead-203是一种SPECT发射器,可用于治疗诊断应用中,作为铅212的成像对应物,旨在作为铅212/铋212体内发生器用于α治疗。在我们的研究中,我们探索使用氘束辐照的富集th205靶生产铅203。氘的激发函数诱导的反应导致204m的形成,203m2+m1+g,202m,201m+gPb,在21MeV至34MeV的能量范围内,实验确定了202Tl和203mgHg同位素。使用堆叠箔技术和一组两个监测箔测量横截面,natNi和natTi用于光束强度评估。将所研究反应的实验激发函数与已发布的数据以及TENDL-2021核数据库进行了比较。根据我们的实验数据,我们计算出在30MeV至32.5MeV之间的能量范围内的铅203厚目标产率为56.7MBq/μAh±6.1MBq/μAh。此值与大批量生产兼容,表明氘光束可用于常规生产过程。然而,必须特别注意203Hg和其他铅污染物。