Abstract：
In recent years, the utilization of medical devices has gradually increased and implantation procedures have become common treatments. However, patients are susceptible to the risk of implant infections. This study utilized chemical grafting to immobilize polyethylenimine (QPEI) and hyaluronic acid (HA) on the surface of the mesh to improve biocompatibility while being able to achieve antifouling antimicrobial effects. From the in vitro testing, PP-PDA-Q-HA exhibited a high antibacterial ratio of 93% against S. aureus, 93% against E. coli, and 85% against C. albicans. In addition, after five rounds of antimicrobial testing, the coating continued to exhibit excellent antimicrobial properties; PP-PDA-Q-HA also inhibits the formation of bacterial biofilms. In addition, PP-PDA-Q-HA has good hemocompatibility and cytocompatibility. In vivo studies in animal implantation infection models also demonstrated the excellent antimicrobial properties of PP-PDA-Q-HA. Our study provides a promising strategy for the development of antimicrobial surface medical materials with excellent biocompatibility.
摘要：
近年来,医疗设备的使用逐渐增加，植入程序已成为常见的治疗方法。然而,患者容易受到植入物感染的风险。这项研究利用化学接枝将聚乙烯亚胺（QPEI）和透明质酸（HA）固定在网格表面，以提高生物相容性，同时能够实现防污抗菌效果。从体外测试来看，PP-PDA-Q-HA对金黄色葡萄球菌具有93%的高抗菌率,93%对大肠杆菌，和85%的白色念珠菌。此外,经过五轮抗菌测试，涂层继续表现出优异的抗微生物性能;PP-PDA-Q-HA还抑制细菌生物膜的形成。此外,PP-PDA-Q-HA具有良好的血液相容性和细胞相容性。在动物植入感染模型中的体内研究也证明了PP-PDA-Q-HA的优异的抗微生物性质。我们的研究为开发具有优异生物相容性的抗菌表面医用材料提供了有希望的策略。
