PDF(Pubmed)
Abstract：
Capsaicin, which is abundant in chili peppers, exerts antioxidative, antitumor, antiulcer and analgesic effects and it has demonstrated potential as a treatment for cardiovascular, gastrointestinal, oncological and dermatological conditions. Unique among natural irritants, capsaicin initially excites neurons but then \'calms\' them into long‑lasting non‑responsiveness. Capsaicin can also promote weight loss, making it potentially useful for treating obesity. Several mechanisms have been proposed to explain the therapeutic effects of capsaicin, including antioxidation, analgesia and promotion of apoptosis. Some of the mechanisms are proposed to be mediated by the capsaicin receptor (transient receptor potential cation channel subfamily V member 1), but some are proposed to be independent of that receptor. The clinical usefulness of capsaicin is limited by its short half‑life. The present review provided an overview of what is known about the therapeutic effects of capsaicin and the mechanisms involved and certain studies arguing against its clinical use were mentioned.
摘要：
辣椒素,辣椒中含有丰富的辣椒，发挥抗氧化作用，抗肿瘤，抗溃疡和镇痛作用，它已经证明了作为心血管治疗的潜力，胃肠,肿瘤和皮肤病学条件。在天然刺激物中独一无二，辣椒素最初会激发神经元，但随后会使它们变得持久无反应。辣椒素还可以促进减肥，使其有可能用于治疗肥胖症。已经提出了几种机制来解释辣椒素的治疗作用，包括抗氧化，镇痛和促进细胞凋亡。一些机制被认为是由辣椒素受体（瞬时受体电位阳离子通道亚家族V成员1）介导的，但有些被认为是独立于该受体的。辣椒素的临床用途受到其半衰期短的限制。本综述概述了有关辣椒素的治疗作用及其机制的已知知识，并提到了某些反对其临床应用的研究。
