PDF(Pubmed)
Abstract：
In patients with esophageal squamous cell carcinoma (ESCC), the incidence and mortality rate of ESCC in our country are also higher than those in the rest of the world. Despite advances in the treatment department method, patient survival rates have not obviously improved, which often leads to treatment obstruction and cancer repeat. ESCC has special cells called cancer stem-like cells (CSLCs) with self-renewal and differentiation ability, which reflect the development process and prognosis of cancer. In this review, we evaluated CSLCs, which are identified from the expression of cell surface markers in ESCC. By inciting EMTs to participate in tumor migration and invasion, stem cells promote tumor redifferentiation. Some factors can inhibit the migration and invasion of ESCC via the EMT-related pathway. We here summarize the research progress on the surface markers of CSLCs, EMT pathway, and the microenvironment in the process of tumor growth. Thus, these data may be more valuable for clinical applications.
摘要：
在食管鳞状细胞癌（ESCC）患者中，我国ESCC的发病率和死亡率也高于世界其他地区。尽管治疗部门方法取得了进展，患者生存率没有明显提高，这通常会导致治疗阻塞和癌症重复。ESCC具有自我更新和分化能力的特殊细胞，称为癌症干细胞样细胞（CSLCs），这反映了癌症的发展过程和预后。在这次审查中,我们评估了CSLCs，从ESCC中细胞表面标志物的表达鉴定。通过激发EMT参与肿瘤的迁移和侵袭，干细胞促进肿瘤再分化。一些因素可以通过EMT相关途径抑制ESCC的迁移和侵袭。我们在这里总结了CSLCs表面标记的研究进展，EMT通路,以及肿瘤生长过程中的微环境。因此，这些数据可能对临床应用更有价值。
