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Abstract：
UNASSIGNED: Sepsis and septic shock are the leading causes of critical care-related mortality worldwide. This study aimed to determine the prevalence of sepsis, its intensive care unit (ICU) mortality rate and the factors associated with both ICU mortality and prolonged stay.
UNASSIGNED: A prospective cohort study was conducted from January 2019 to December 2019 with adult patients presenting evidence of sepsis who were admitted to the ICU. Parameters were assessed in the ICU to determine the association with all-cause ICU mortality and prolonged stay.
UNASSIGNED: Out of 607 adults, 292 with sepsis were admitted to the ICU in 2019, with a mean age of 50.98 (standard deviation [SD] = 17.75) years old. There was, thus, a 48% incidence of sepsis. Mortality was observed in 78 patients (mortality rate = 26.7%) (95% confidence interval [CI]: 21.7, 32.2). Patients with higher Glasgow coma scale (GCS) scores had lower odds of ICU mortality (adjusted odds ratio [OR] = 0.90; 95% CI: 0.82, 0.98; P = 0.019), while patients with higher sequential organ failure assessment (SOFA) scores had higher odds (adjusted OR = 1.22; 95% CI: 1.11, 1.35; P < 0.001). Eighty patients (37.4%) who survived had prolonged ICU stays (95% CI: 30.9, 44.2). Patients with higher albumin levels had lower odds of a prolonged ICU stay (adjusted OR = 0.94; 95% CI: 0.90, 0.98; P = 0.006) and patients on renal replacement therapy had higher odds of a prolonged ICU stay (adjusted OR = 1.25; 95% CI: 1.74, 7.12; P < 0.001).
UNASSIGNED: Our study identified a sepsis prevalence of 48% and an ICU mortality rate of 26.7% among adult patients admitted to the ICU. GCS and SOFA scores were the most important factors associated with ICU mortality.
UNASSIGNED: A prospective cohort study was conducted from January 2019 to December 2019 with adult patients presenting evidence of sepsis who were admitted to the ICU. Parameters were assessed in the ICU to determine the association with all-cause ICU mortality and prolonged stay.
UNASSIGNED: Out of 607 adults, 292 with sepsis were admitted to the ICU in 2019, with a mean age of 50.98 (standard deviation [SD] = 17.75) years old. There was, thus, a 48% incidence of sepsis. Mortality was observed in 78 patients (mortality rate = 26.7%) (95% confidence interval [CI]: 21.7, 32.2). Patients with higher Glasgow coma scale (GCS) scores had lower odds of ICU mortality (adjusted odds ratio [OR] = 0.90; 95% CI: 0.82, 0.98; P = 0.019), while patients with higher sequential organ failure assessment (SOFA) scores had higher odds (adjusted OR = 1.22; 95% CI: 1.11, 1.35; P < 0.001). Eighty patients (37.4%) who survived had prolonged ICU stays (95% CI: 30.9, 44.2). Patients with higher albumin levels had lower odds of a prolonged ICU stay (adjusted OR = 0.94; 95% CI: 0.90, 0.98; P = 0.006) and patients on renal replacement therapy had higher odds of a prolonged ICU stay (adjusted OR = 1.25; 95% CI: 1.74, 7.12; P < 0.001).
UNASSIGNED: Our study identified a sepsis prevalence of 48% and an ICU mortality rate of 26.7% among adult patients admitted to the ICU. GCS and SOFA scores were the most important factors associated with ICU mortality.
摘要：
脓毒症和脓毒性休克是全球重症监护相关死亡的主要原因。本研究旨在确定脓毒症的患病率，其重症监护病房（ICU）死亡率以及与ICU死亡率和住院时间相关的因素。
于2019年1月至2019年12月进行了一项前瞻性队列研究，研究对象是有脓毒症证据的成年患者，这些患者被送入ICU。在ICU中评估参数，以确定与全因ICU死亡率和住院时间的关系。
■在607名成年人中，2019年有292例脓毒症患者入住ICU，平均年龄为50.98岁(标准差[SD]=17.75)。有,因此，脓毒症发生率为48%。在78例患者中观察到死亡率（死亡率=26.7％）（95％置信区间[CI]：21.7，32.2）。格拉斯哥昏迷量表（GCS）评分较高的患者ICU死亡的几率较低（调整后的比值比[OR]=0.90；95％CI：0.82，0.98；P=0.019）。而序贯器官衰竭评估（SOFA）评分较高的患者的几率较高（校正后OR=1.22；95％CI：1.11，1.35；P<0.001）。存活的80例患者（37.4％）ICU住院时间延长（95％CI：30.9，44.2）。白蛋白水平较高的患者ICU住院时间延长的几率较低（校正后OR=0.94；95%CI：0.90，0.98；P=0.006），接受肾脏替代治疗的患者ICU住院时间延长的几率较高（校正后OR=1.25；95%CI：1.74，7.12；P<0.001）。
■我们的研究发现，在入住ICU的成年患者中，脓毒症患病率为48%，ICU死亡率为26.7%。GCS和SOFA评分是与ICU死亡率相关的最重要因素。
于2019年1月至2019年12月进行了一项前瞻性队列研究，研究对象是有脓毒症证据的成年患者，这些患者被送入ICU。在ICU中评估参数，以确定与全因ICU死亡率和住院时间的关系。
■在607名成年人中，2019年有292例脓毒症患者入住ICU，平均年龄为50.98岁(标准差[SD]=17.75)。有,因此，脓毒症发生率为48%。在78例患者中观察到死亡率（死亡率=26.7％）（95％置信区间[CI]：21.7，32.2）。格拉斯哥昏迷量表（GCS）评分较高的患者ICU死亡的几率较低（调整后的比值比[OR]=0.90；95％CI：0.82，0.98；P=0.019）。而序贯器官衰竭评估（SOFA）评分较高的患者的几率较高（校正后OR=1.22；95％CI：1.11，1.35；P<0.001）。存活的80例患者（37.4％）ICU住院时间延长（95％CI：30.9，44.2）。白蛋白水平较高的患者ICU住院时间延长的几率较低（校正后OR=0.94；95%CI：0.90，0.98；P=0.006），接受肾脏替代治疗的患者ICU住院时间延长的几率较高（校正后OR=1.25；95%CI：1.74，7.12；P<0.001）。
■我们的研究发现，在入住ICU的成年患者中，脓毒症患病率为48%，ICU死亡率为26.7%。GCS和SOFA评分是与ICU死亡率相关的最重要因素。
