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Abstract：
BACKGROUND: To date, few reports have evaluated the long-term outcome of percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs) and the factors influencing the long-term outcome of this procedure are uncertain.
METHODS: A total of 91 patients underwent PKP for thoracolumbar OVCFs from June 2012 to December 2012. Pain Visual Analogue Scores (VAS) and Oswestry Disability Index (ODI) were recorded preoperatively and after 10-year follow-up. Factors that may affect surgical outcome, such as gender, age, height, weight, hypertension, diabetes, cause of injury, fracture segment, length of hospitalization, history of previous spinal surgery, preoperative bone mineral density (BMD), preoperative VAS and ODI scores, length of surgery, bone cement dosage, postoperative standardized anti-osteoporosis treatment, and other new vertebral fractures, were analyzed by multiple linear regression with VAS and ODI scores at the last follow-up. The correlation factors affecting the efficacy were analyzed.
RESULTS: The preoperative and final follow-up pain VAS was 7.9 ± 1.1 and 2.2 ± 1.1. ODI scores were 30.4 ± 4.2 and 10.7 ± 2.6. The difference was statistically significant (P < 0.05). Most of the patients were females aged 65-75 years who suffered low-energy injuries, with most of the fracture segments in the thoracolumbar region (T11-L2). At the final follow-up visit, 12 cases (13.19%) developed other new vertebral fractures, and 33 cases (36.26%) continued to adhere to anti-osteoporosis treatment after discharge. Multiple linear regression analysis showed that there was a statistical difference between gender and VAS score at the last follow-up (P < 0.05), and between age, cause of injury and postoperative standardized anti-osteoporosis treatment and ODI at the last follow-up (P < 0.05). There were no statistically significant differences between the other factors and the final follow-up VAS and ODI scores (P > 0.05).
CONCLUSIONS: The long-term outcome after PKP is satisfactory. Age, gender, cause of injury, and standardized postoperative anti-osteoporosis treatment may be factors affecting the long-term outcome.
METHODS: A total of 91 patients underwent PKP for thoracolumbar OVCFs from June 2012 to December 2012. Pain Visual Analogue Scores (VAS) and Oswestry Disability Index (ODI) were recorded preoperatively and after 10-year follow-up. Factors that may affect surgical outcome, such as gender, age, height, weight, hypertension, diabetes, cause of injury, fracture segment, length of hospitalization, history of previous spinal surgery, preoperative bone mineral density (BMD), preoperative VAS and ODI scores, length of surgery, bone cement dosage, postoperative standardized anti-osteoporosis treatment, and other new vertebral fractures, were analyzed by multiple linear regression with VAS and ODI scores at the last follow-up. The correlation factors affecting the efficacy were analyzed.
RESULTS: The preoperative and final follow-up pain VAS was 7.9 ± 1.1 and 2.2 ± 1.1. ODI scores were 30.4 ± 4.2 and 10.7 ± 2.6. The difference was statistically significant (P < 0.05). Most of the patients were females aged 65-75 years who suffered low-energy injuries, with most of the fracture segments in the thoracolumbar region (T11-L2). At the final follow-up visit, 12 cases (13.19%) developed other new vertebral fractures, and 33 cases (36.26%) continued to adhere to anti-osteoporosis treatment after discharge. Multiple linear regression analysis showed that there was a statistical difference between gender and VAS score at the last follow-up (P < 0.05), and between age, cause of injury and postoperative standardized anti-osteoporosis treatment and ODI at the last follow-up (P < 0.05). There were no statistically significant differences between the other factors and the final follow-up VAS and ODI scores (P > 0.05).
CONCLUSIONS: The long-term outcome after PKP is satisfactory. Age, gender, cause of injury, and standardized postoperative anti-osteoporosis treatment may be factors affecting the long-term outcome.
摘要：
背景：迄今为止，很少有报道评估经皮椎体后凸成形术(PKP)治疗骨质疏松性椎体压缩性骨折(OVCFs)的长期结局,影响该手术长期结局的因素尚不确定.
方法：2012年6月至2012年12月，共有91例患者接受了胸腰椎OVCFsPKP治疗。术前和随访10年后记录疼痛视觉模拟评分（VAS）和Oswestry残疾指数（ODI）。可能影响手术结果的因素，比如性别,年龄,高度,体重,高血压,糖尿病,受伤原因,骨折段,住院时间,既往脊柱手术史,术前骨密度（BMD），术前VAS和ODI评分，手术长度,骨水泥用量,术后规范化抗骨质疏松治疗,和其他新的椎骨骨折，采用多元线性回归分析末次随访时的VAS和ODI评分。分析影响疗效的相关因素。
结果：术前和最终随访疼痛VAS分别为7.9±1.1和2.2±1.1。ODI评分分别为30.4±4.2和10.7±2.6。差异有统计学意义(P<0.05)。大多数患者是65-75岁的女性，他们遭受了低能量伤害，大部分骨折节段在胸腰椎区（T11-L2）。在最后的后续访问中，12例（13.19%）出现其他新的椎体骨折，出院后继续坚持抗骨质疏松治疗33例(36.26%)。多元线性回归分析显示末次随访时性别、VAS评分差异有统计学意义(P<0.05),和年龄之间，损伤原因及术后规范抗骨质疏松治疗和末次随访ODI(P<0.05)。其他因素与末次随访VAS、ODI评分比较差异均无统计学意义(P>0.05)。
结论：PKP术后的长期结果令人满意。年龄,性别,受伤原因,术后规范化抗骨质疏松治疗可能是影响远期预后的因素。
方法：2012年6月至2012年12月，共有91例患者接受了胸腰椎OVCFsPKP治疗。术前和随访10年后记录疼痛视觉模拟评分（VAS）和Oswestry残疾指数（ODI）。可能影响手术结果的因素，比如性别,年龄,高度,体重,高血压,糖尿病,受伤原因,骨折段,住院时间,既往脊柱手术史,术前骨密度（BMD），术前VAS和ODI评分，手术长度,骨水泥用量,术后规范化抗骨质疏松治疗,和其他新的椎骨骨折，采用多元线性回归分析末次随访时的VAS和ODI评分。分析影响疗效的相关因素。
结果：术前和最终随访疼痛VAS分别为7.9±1.1和2.2±1.1。ODI评分分别为30.4±4.2和10.7±2.6。差异有统计学意义(P<0.05)。大多数患者是65-75岁的女性，他们遭受了低能量伤害，大部分骨折节段在胸腰椎区（T11-L2）。在最后的后续访问中，12例（13.19%）出现其他新的椎体骨折，出院后继续坚持抗骨质疏松治疗33例(36.26%)。多元线性回归分析显示末次随访时性别、VAS评分差异有统计学意义(P<0.05),和年龄之间，损伤原因及术后规范抗骨质疏松治疗和末次随访ODI(P<0.05)。其他因素与末次随访VAS、ODI评分比较差异均无统计学意义(P>0.05)。
结论：PKP术后的长期结果令人满意。年龄,性别,受伤原因,术后规范化抗骨质疏松治疗可能是影响远期预后的因素。
