PDF(Pubmed)
Abstract：
UNASSIGNED: The global increase in human life expectancy is evident. The total number of individuals aged 60 or above is anticipated to reach 2 billion by 2050. Aging, an inherently complex process, manifests prominently in the changes observed in the immune system. A notable marker of immune system aging is the presence of Aging-Related Immune Cell Phenotypes (ARIPs). Despite their significance, the connections between various ARIPs and mortality have not been thoroughly investigated. We prospectively investigated 16 different ARIPs using flow cytometry, namely, CD4/CD8 ratio, Granzyme B + CD8/Granyzme B + CD4, TN/TM = Tn / (Teff + Tem + Tcm) for TN/TM CD4 + and TN/TM CD8 + ratios, Th17/CD4 + Treg, Tc17/CD8 + Treg, Th17, Tc17, CD4 + Temra, CD8 + Temra, CD4 + CD25 + FoxP3+ (CD4 + Treg), CD8 + CD25 + FoxP3+ (CD8 + Treg) CD4 + CD27-, CD4 + CD28-CD27-, CD8 + CD27-, CD8 + CD28-CD27- and IL-6 in relation to survival outcome among dementia-free Framingham Heart Study (FHS) offspring cohort participants who attended the seventh exam (1998-2001).
UNASSIGNED: Among 996 participants (mean age 62 years, range 40 to 88 years, 52% female), the survival rate was 65% during 19 years of follow-up. For the model adjusting for age, sex, and cytomegalovirus (CMV) serostatus, higher CD4/CD8 and Tc17/CD8 + Treg ratios were significantly associated with lower all-cause mortality (HR:0.86 [0.76-0.96], 0.84 [0.74-0.94], respectively) and higher CD8 regulatory cell levels (CD8 + CD25 + FoxP3+) were associated with higher all-cause mortality (HR = 1.17, [1.03-1.32]). Higher IL-6 levels were associated with higher all-cause, cardiovascular, and non-cardiovascular mortality (HR = 1.43 [1.26-1.62], 1.70 [1.31-2.21], and 1.36 [1.18-1.57], respectively).
UNASSIGNED: Among 996 participants (mean age 62 years, range 40 to 88 years, 52% female), the survival rate was 65% during 19 years of follow-up. For the model adjusting for age, sex, and cytomegalovirus (CMV) serostatus, higher CD4/CD8 and Tc17/CD8 + Treg ratios were significantly associated with lower all-cause mortality (HR:0.86 [0.76-0.96], 0.84 [0.74-0.94], respectively) and higher CD8 regulatory cell levels (CD8 + CD25 + FoxP3+) were associated with higher all-cause mortality (HR = 1.17, [1.03-1.32]). Higher IL-6 levels were associated with higher all-cause, cardiovascular, and non-cardiovascular mortality (HR = 1.43 [1.26-1.62], 1.70 [1.31-2.21], and 1.36 [1.18-1.57], respectively).
摘要：
背景技术人类预期寿命的全球增长是显而易见的。到2050年，60岁或以上的总人数预计将达到20亿。衰老,一个内在复杂的过程，在免疫系统中观察到的变化中表现突出。免疫系统衰老的一个值得注意的标记是衰老相关免疫细胞表型(ARIP)的存在。尽管意义重大,各种ARIPs与死亡率之间的联系尚未得到彻底调查.我们使用流式细胞术前瞻性地调查了16种不同的ARIP，即,CD4/CD8比值,颗粒酶B+CD8/GranyzmeB+CD4,TN/TM=TN/TMCD4+和TN/TMCD8+比值的TN/TMM=Tn/(Teff+Tem+Tcm),Th17/CD4+Treg,Tc17/CD8+Treg,Th17,Tc17,CD4+Temra,CD8+Temra,CD4+CD25+FoxP3+(CD4+Treg),CD8+CD25+FoxP3+(CD8+Treg)CD4+CD27-,CD4+CD28-CD27-,CD8+CD27-,CD8+CD28-CD27-和IL-6与无痴呆的弗雷明汉心脏研究（FHS）后代队列参与者参加了第七次检查（1998-2001）的生存结果的关系。结果996名参与者(平均年龄62岁，40到88年，52%女性），19年随访期间生存率为65%.对于调整年龄的模型，性别,和巨细胞病毒（CMV）血清状态，较高的CD4/CD8和Tc17/CD8+Treg比率与较低的全因死亡率显著相关(HR:0.86[0.76-0.96],0.84[0.74-0.94],分别）和更高的CD8调节细胞水平（CD8+CD25+FoxP3+）与更高的全因死亡率相关（HR=1.17，[1.03-1.32]）。较高的IL-6水平与较高的全因，心血管,和非心血管死亡率(HR=1.43[1.26-1.62]，1.70[1.31-2.21]，和1.36[1.18-1.57]，分别)。
