PDF(Pubmed)
Abstract：
In recent years, small non-coding RNAs (ncRNAs) have emerged as a new player in the realm of cancer therapeutics. Their unique capacity to directly modulate genetic networks and target oncogenes positions them as valuable complements to existing small-molecule drugs. Concurrently, the advancement of small ncRNA-based therapeutics has rekindled the pursuit of efficacious in vivo delivery strategies. In this review, we provide an overview of the most current clinical and preclinical studies in the field of small ncRNA-based cancer therapeutics. Furthermore, we shed light on the pivotal challenges hindering the successful translation of these promising therapies into clinical practice, with a specific focus on delivery methods, aiming to stimulate innovative approaches to address this foundational aspect of cancer treatment.
摘要：
近年来,小的非编码RNA（ncRNA）已经成为癌症治疗领域的新参与者。它们直接调节遗传网络和靶向癌基因的独特能力将它们定位为现有小分子药物的有价值的补充。同时,基于ncRNA的小疗法的发展重新点燃了对有效体内递送策略的追求.在这次审查中,我们概述了基于小ncRNA的癌症治疗领域的最新临床和临床前研究。此外，我们揭示了阻碍这些有前途的疗法成功转化为临床实践的关键挑战，特别关注交付方法，旨在刺激创新方法来解决癌症治疗的这一基本方面。
