PDF(Pubmed)
Abstract：
Gestational diabetes mellitus is a prevalent metabolic disease that can impact the normal course of pregnancy and delivery, leading to adverse outcomes for both mother and child. Its pathogenesis is complex and involves various factors, such as insulin resistance and β-cell dysfunction. Metabolic reprogramming, which involves mitochondrial oxidative phosphorylation and glycolysis, is crucial for maintaining human metabolic balance and is involved in the pathogenesis and progression of gestational diabetes mellitus. However, research on the link and metabolic pathways between metabolic reprogramming and gestational diabetes mellitus is limited. Therefore, we reviewed the relationship between metabolic reprogramming and gestational diabetes mellitus to provide new therapeutic strategies for maternal health during pregnancy and reduce the risk of developing gestational diabetes mellitus.
摘要：
妊娠期糖尿病是一种常见的代谢性疾病，可影响妊娠和分娩的正常过程。导致母亲和孩子的不良后果。其发病机制复杂,涉及多种因素,如胰岛素抵抗和β细胞功能障碍。代谢重编程，涉及线粒体氧化磷酸化和糖酵解，对于维持人体代谢平衡至关重要，并且与妊娠期糖尿病的发病机制和进展有关。然而,关于代谢重编程与妊娠期糖尿病之间的联系和代谢途径的研究是有限的。因此,我们综述了代谢重编程与妊娠期糖尿病之间的关系，以期为妊娠期孕产妇健康提供新的治疗策略，降低妊娠期糖尿病的风险。
