Abstract：
OBJECTIVE: A multisociety consensus group proposed a new nomenclature for metabolic dysfunction-associated steatotic liver disease (MASLD). Although patients with nonalcoholic fatty liver disease (NAFLD) are expected to be reclassified as patients with MASLD under the new nomenclature, the concordance between MASLD and NAFLD remains unclear. Moreover, waist circumference could be adjusted by ethnicity for diagnosing MASLD; however, there are limited data on the optimal waist circumference in the Japanese population.
METHODS: This cross-sectional study was conducted on 3709 Japanese patients with NAFLD. The primary endpoint was the prevalence of MASLD in patients with NAFLD. The difference between the original waist circumference criteria (>94 cm for men and >80 cm for women) and the Japanese metabolic syndrome criteria (≥85 cm for men and ≥90 cm for women) for concordance between NAFLD and MASLD was also investigated.
RESULTS: According to the original criteria, the prevalence of MASLD in patients with NAFLD was 96.7%. Similarly, according to the Japanese waist circumference criteria, 96.2% of patients with NAFLD could be reclassified as those with MASLD. The concordance rate was significantly higher in the original criteria than in the Japanese criteria (p = 0.02).
CONCLUSIONS: NAFLD could be considered MASLD using the original MASLD criteria in the Japanese population, and insights from NAFLD research could be applied to MASLD.
METHODS: This cross-sectional study was conducted on 3709 Japanese patients with NAFLD. The primary endpoint was the prevalence of MASLD in patients with NAFLD. The difference between the original waist circumference criteria (>94 cm for men and >80 cm for women) and the Japanese metabolic syndrome criteria (≥85 cm for men and ≥90 cm for women) for concordance between NAFLD and MASLD was also investigated.
RESULTS: According to the original criteria, the prevalence of MASLD in patients with NAFLD was 96.7%. Similarly, according to the Japanese waist circumference criteria, 96.2% of patients with NAFLD could be reclassified as those with MASLD. The concordance rate was significantly higher in the original criteria than in the Japanese criteria (p = 0.02).
CONCLUSIONS: NAFLD could be considered MASLD using the original MASLD criteria in the Japanese population, and insights from NAFLD research could be applied to MASLD.
摘要：
目的：一个多社会共识小组提出了代谢功能障碍相关的脂肪变性肝病（MASLD）的新命名法。尽管非酒精性脂肪性肝病（NAFLD）患者在新的命名法下有望被重新分类为MASLD患者，MASLD和NAFLD之间的一致性尚不清楚.此外，腰围可以根据种族进行调整，以诊断MASLD；然而，关于日本人群最佳腰围的数据有限。
方法：这项横断面研究是对3709名日本NAFLD患者进行的。主要终点是NAFLD患者中MASLD的患病率。还调查了原始腰围标准（男性>94厘米，女性>80厘米）和日本代谢综合征标准（男性≥85厘米，女性≥90厘米）之间NAFLD和MASLD一致性的差异。
结果：根据原始标准，NAFLD患者中MASLD的患病率为96.7%.同样，根据日本的腰围标准，96.2%的NAFLD患者可以重新分类为MASLD患者。原始标准的一致率显着高于日本标准（p=0.02）。
结论：NAFLD可以被认为是使用日本人口的原始MASLD标准，NAFLD研究的见解可以应用于MASLD。
方法：这项横断面研究是对3709名日本NAFLD患者进行的。主要终点是NAFLD患者中MASLD的患病率。还调查了原始腰围标准（男性>94厘米，女性>80厘米）和日本代谢综合征标准（男性≥85厘米，女性≥90厘米）之间NAFLD和MASLD一致性的差异。
结果：根据原始标准，NAFLD患者中MASLD的患病率为96.7%.同样，根据日本的腰围标准，96.2%的NAFLD患者可以重新分类为MASLD患者。原始标准的一致率显着高于日本标准（p=0.02）。
结论：NAFLD可以被认为是使用日本人口的原始MASLD标准，NAFLD研究的见解可以应用于MASLD。
