Abstract：
OBJECTIVE: The prevalence of osteoporosis (OP) and insufficiency fractures in psoriatic arthritis (PsA) remains controversial. The aim of this study was to describe the prevalence of OP and insufficiency fractures in a representative cohort of patients with PsA, and to analyse its association with general risk factors and characteristics of the psoriatic disease in our geographical area.
METHODS: Multi-centric, descriptive study of patients with PsA. We recorded clinical characteristics, as well as protective and risk factors for OP and insufficiency fractures. Hip and lumbar densitometry and lateral X-ray of the spine were evaluated. Descriptive statistics for OP and risk factors were calculated. The patients with OP were compared to those without by univariate analyses, and results were adjusted by age and sex. The association of OP and fractures with clinical characteristics was analysed by logistic regression.
RESULTS: 166 patients (50 men; 116 women) were included. OP was present in 26.5%, and it was more frequent in women and patients above 50 years old. Insufficiency fractures occurred in 5.4% of the total sample. In the logistic regression, OP was associated with age over 50 [OR 3.7; 95% CI (1.2-11.6); p=.02]. No association with clinical parameters was found. The most frequent risk factors among patients with OP were vitamin D insufficiency, sedentary behaviour, low calcium intake, and active smoking. In the logistic regression, OP was associated with early menopause [OR 11.7; 95% CI (1.29-106.0); p=.029] and sedentary behaviour [OR 2.3; 95% CI (1.0-5.2); p=.049].
CONCLUSIONS: In patients with PsA, OP is more frequent in women and patients over 50 years old. A sedentary lifestyle and early menopause may add extra risk for OP. Type, duration disease, and treatments are not associated with OP or insufficiency fractures.
METHODS: Multi-centric, descriptive study of patients with PsA. We recorded clinical characteristics, as well as protective and risk factors for OP and insufficiency fractures. Hip and lumbar densitometry and lateral X-ray of the spine were evaluated. Descriptive statistics for OP and risk factors were calculated. The patients with OP were compared to those without by univariate analyses, and results were adjusted by age and sex. The association of OP and fractures with clinical characteristics was analysed by logistic regression.
RESULTS: 166 patients (50 men; 116 women) were included. OP was present in 26.5%, and it was more frequent in women and patients above 50 years old. Insufficiency fractures occurred in 5.4% of the total sample. In the logistic regression, OP was associated with age over 50 [OR 3.7; 95% CI (1.2-11.6); p=.02]. No association with clinical parameters was found. The most frequent risk factors among patients with OP were vitamin D insufficiency, sedentary behaviour, low calcium intake, and active smoking. In the logistic regression, OP was associated with early menopause [OR 11.7; 95% CI (1.29-106.0); p=.029] and sedentary behaviour [OR 2.3; 95% CI (1.0-5.2); p=.049].
CONCLUSIONS: In patients with PsA, OP is more frequent in women and patients over 50 years old. A sedentary lifestyle and early menopause may add extra risk for OP. Type, duration disease, and treatments are not associated with OP or insufficiency fractures.
摘要：
目的：银屑病关节炎（PsA）中骨质疏松（OP）和骨折不全的患病率仍存在争议。这项研究的目的是描述一个代表性的PsA患者队列中OP和功能不全骨折的患病率，并分析其与我们地理区域银屑病的一般危险因素和特征的关系。
方法：多中心，PsA患者的描述性研究。我们记录了临床特征，以及OP和功能不全骨折的保护和危险因素。评估了髋部和腰椎的密度测定以及脊柱的侧面X射线。计算OP和危险因素的描述性统计。通过单变量分析将患有OP的患者与没有OP的患者进行比较，结果按年龄和性别进行调整。采用logistic回归分析OP和骨折与临床特征的关系。
结果：166名患者（50名男性；116名女性）被纳入。OP出现在26.5%，在50岁以上的女性和患者中更为常见。不足骨折发生在总样本的5.4%中。在逻辑回归中，OP与50岁以上年龄相关[OR3.7;95%CI(1.2-11.6);p=.02]。未发现与临床参数相关。OP患者中最常见的危险因素是维生素D不足，久坐的行为，钙摄入量低，积极吸烟。在逻辑回归中，OP与绝经早期[OR11.7;95%CI(1.29-106.0);p=.029]和久坐行为[OR2.3;95%CI(1.0-5.2);p=.049]相关。
结论：在PsA患者中，OP在女性和50岁以上的患者中更常见。久坐的生活方式和早期绝经可能会增加OP的额外风险。类型,持续时间疾病，并且治疗与OP或功能不全骨折无关。
方法：多中心，PsA患者的描述性研究。我们记录了临床特征，以及OP和功能不全骨折的保护和危险因素。评估了髋部和腰椎的密度测定以及脊柱的侧面X射线。计算OP和危险因素的描述性统计。通过单变量分析将患有OP的患者与没有OP的患者进行比较，结果按年龄和性别进行调整。采用logistic回归分析OP和骨折与临床特征的关系。
结果：166名患者（50名男性；116名女性）被纳入。OP出现在26.5%，在50岁以上的女性和患者中更为常见。不足骨折发生在总样本的5.4%中。在逻辑回归中，OP与50岁以上年龄相关[OR3.7;95%CI(1.2-11.6);p=.02]。未发现与临床参数相关。OP患者中最常见的危险因素是维生素D不足，久坐的行为，钙摄入量低，积极吸烟。在逻辑回归中，OP与绝经早期[OR11.7;95%CI(1.29-106.0);p=.029]和久坐行为[OR2.3;95%CI(1.0-5.2);p=.049]相关。
结论：在PsA患者中，OP在女性和50岁以上的患者中更常见。久坐的生活方式和早期绝经可能会增加OP的额外风险。类型,持续时间疾病，并且治疗与OP或功能不全骨折无关。
