Abstract：
Drug release plays a crucial role in drug delivery. While current formulation approaches are capable of coarse-tuning the release profile, their precision and reproducibility are limited by the physicochemical properties of the excipients and active pharmaceutical ingredient (API). Innovative and advanced approaches are urgently needed, especially for site-specific targeting of drugs and to address their pharmacological requirements for optimal therapy. The 5 × 5 × 0.6 mm3 piezoelectric micropump developed by Fraunhofer EMFT was designed to enable precise drug delivery in a low volume format. In this study, we investigated the ability of the micropump to deliver solutions of highly soluble APIs using a wide range of customized pump profiles. Additionally, we examined the ability of the micropump to deliver suspensions containing various defined particle sizes. While results for suspensions indicate that pumping performance is highly dependent on the size and concentration of the suspended particles, results with API solutions demonstrate high precision and reproducibility of release, coupled with maximum flexibility in the release profile of the API. The piezoelectric micropump thus lays the cornerstone in the development of a wide range of innovative drug delivery profiles, enabling customized release profiles to be programmed and thus paving the way to fully personalized medicine.
摘要：
药物释放在药物递送中起着至关重要的作用。虽然目前的配方方法能够粗调释放曲线，赋形剂和活性药物成分（API）的物理化学性质限制了它们的精度和可重复性。迫切需要创新和先进的方法，特别是针对药物的位点特异性靶向，并满足其最佳治疗的药理学要求。FraunhoferEMFT开发的5×5×0.6mm3压电微泵旨在以低体积形式进行精确的药物输送。在这项研究中,我们研究了微泵使用各种定制泵配置文件提供高可溶性API溶液的能力.此外,我们检查了微型泵输送含有各种确定粒径的悬浮液的能力。虽然悬浮液的结果表明，泵送性能高度依赖于悬浮颗粒的大小和浓度，API溶液的结果证明了释放的高精度和重现性，再加上API的发布配置文件的最大灵活性。因此，压电微泵为开发广泛的创新药物输送概况奠定了基石，使定制的释放配置文件能够被编程，从而为完全个性化的医疗铺平了道路。
