PDF(Pubmed)
Abstract：
Basidiobolomycosis is an uncommon fungal infection caused by the genus Basidiobolus. In immunocompetent children, it usually causes cutaneous infection and rarely affects the gastrointestinal tract, and it is extremely rare for the disease to spread. The present study reports the first case of disseminated basidiobolomycosis caused by Basidiobolus omanensis in a child with acute lymphoblastic leukemia who died as a result of uncontrolled infection and multi-organ failure despite surgical and antifungal therapy with L-AMB and voriconazole. A review of the literature yielded 76 cases, including the current case with the majority of which were reported as invasive gastrointestinal infection. The median age was 4 years (61 male and 15 female) and the majority of these children were from the Middle East (80%), specifically Saudi Arabia (45%). Most patients were treated with systemic antifungal agents (mostly itraconazole and amphotericin B). Surgical intervention was done in 25% of these patients and the death rate was 12%.
摘要：
担子菌病是由担子菌属引起的罕见真菌感染。在有免疫能力的儿童中，它通常会引起皮肤感染，很少影响胃肠道，这种疾病的传播极为罕见。本研究报告了第一例由OmanensisBasidiobolusomanensis引起的播散性担子菌病，该儿童患有急性淋巴细胞白血病，尽管接受了L-AMB和伏立康唑的手术和抗真菌治疗，但由于不受控制的感染和多器官衰竭而死亡。文献回顾产生了76例，包括目前的病例，其中大部分报告为侵袭性胃肠道感染。平均年龄为4岁（61名男性和15名女性），这些儿童中的大多数来自中东（80％），特别是沙特阿拉伯（45%）。大多数患者接受全身抗真菌药物（主要是伊曲康唑和两性霉素B）治疗。这些患者中有25％进行了手术干预，死亡率为12％。
