PDF(Pubmed)
Abstract：
Recent evidence highlights the role of low-grade synovial inflammation in the progression of osteoarthritis (OA). Inflamed synovium of OA joints detected by imaging modalities are associated with subsequent progression of OA. In this sense, detecting and quantifying synovitis of OA by imaging modalities may be valuable in predicting OA progressors as well as in improving our understanding of OA progression. Of the several imaging modalities, molecular imaging such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) has an advantage of visualizing the cellular or subcellular events of the tissues. Depending on the radiotracers used, molecular imaging method can potentially detect and visualize various aspects of synovial inflammation. This narrative review summarizes the recent progresses of imaging modalities in assessing inflammation and OA synovitis and focuses on novel radiotracers. Recent studies about imaging modalities including ultrasonography (US), magnetic resonance imaging (MRI), and molecular imaging that were used to detect and quantify inflammation and OA synovitis are summarized. Novel radiotracers specifically targeting the components of inflammation have been developed. These tracers may show promise in detecting inflamed synovium of OA and help in expanding our understanding of OA progression.
摘要：
最近的证据强调了低度滑膜炎症在骨关节炎（OA）进展中的作用。通过成像方式检测到的OA关节滑膜发炎与随后的OA进展相关。在这个意义上,通过影像学检查方式检测和量化OA滑膜炎可能对预测OA进展以及提高我们对OA进展的认识有价值.在几种成像模式中，分子成像，如正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）具有可视化组织的细胞或亚细胞事件的优势。根据使用的放射性示踪剂，分子成像方法可以潜在地检测和可视化滑膜炎症的各个方面。这篇叙述性综述总结了成像方式在评估炎症和OA滑膜炎方面的最新进展，并着重于新型放射性示踪剂。最近关于成像模式的研究，包括超声检查（US），磁共振成像（MRI），总结了用于检测和量化炎症和OA滑膜炎的分子影像学。已经开发了特异性靶向炎症组分的新型放射性示踪剂。这些示踪剂可能在检测OA发炎的滑膜方面显示出希望，并有助于扩大我们对OA进展的理解。
