PDF(Pubmed)
Abstract：
BACKGROUND: Neonatal lupus erythematosus (NLE) is a rare autoimmune disease, which needs to be distinguished from eczema, congenital syphilis, and tinea corporis in newborns. Reflectance confocal microscopy (RCM) could be a helpful noninvasive diagnostic tool, which has been used to evaluate several inflammatory skin conditions. The aim of this study was to describe the RCM characteristics of NLE.
METHODS: Eleven NLE patients were included in the study, and all patients were evaluated clinically with RCM. We also evaluated RCM images from 11 eczema patients as controls.
RESULTS: Some major key diagnostic features of NLE can be observed by RCM: an enlarged honeycomb pattern (9/11, 81.8%), round-to-oval cyst-like structures were present (6/11, 54.5%), the normal ring-like structures were totally or partially obliterated (11/11, 100%) at the level of the dermo-epidermal junction, medium refractivity collagen fibers that were disorganized (10/11, 90.9%), numerous high refractivity round cells (11/11, 100%) in the dermis.
CONCLUSIONS: RCM allows the visualization of major key diagnostic features of NLE and serves as a complementary diagnostic tool for NLE.
METHODS: Eleven NLE patients were included in the study, and all patients were evaluated clinically with RCM. We also evaluated RCM images from 11 eczema patients as controls.
RESULTS: Some major key diagnostic features of NLE can be observed by RCM: an enlarged honeycomb pattern (9/11, 81.8%), round-to-oval cyst-like structures were present (6/11, 54.5%), the normal ring-like structures were totally or partially obliterated (11/11, 100%) at the level of the dermo-epidermal junction, medium refractivity collagen fibers that were disorganized (10/11, 90.9%), numerous high refractivity round cells (11/11, 100%) in the dermis.
CONCLUSIONS: RCM allows the visualization of major key diagnostic features of NLE and serves as a complementary diagnostic tool for NLE.
摘要：
背景：新生儿红斑狼疮（NLE）是一种罕见的自身免疫性疾病，需要区分湿疹，先天性梅毒,和新生儿的体癣。反射共聚焦显微镜（RCM）可能是一种有用的非侵入性诊断工具，已用于评估几种炎症性皮肤状况。本研究的目的是描述NLE的RCM特征。
方法：将9例NLE患者纳入研究，所有患者均采用RCM进行临床评估.我们还评估了9例湿疹患者作为对照的RCM图像。
结果：RCM可以观察到NLE的一些主要关键诊断特征，扩大的蜂窝图案（7/9，78%），存在圆形至卵圆形囊肿样结构（6/9，67%），正常的环状结构在真皮-表皮交界处完全或部分消失（9/9，100％），中等折射率杂乱无章的粗纤维材料（8/9，89%），大量高折射率圆形细胞（9/9，100％）在真皮。
结论：RCM可以可视化NLE的主要关键诊断特征，并作为NLE的补充诊断工具。
方法：将9例NLE患者纳入研究，所有患者均采用RCM进行临床评估.我们还评估了9例湿疹患者作为对照的RCM图像。
结果：RCM可以观察到NLE的一些主要关键诊断特征，扩大的蜂窝图案（7/9，78%），存在圆形至卵圆形囊肿样结构（6/9，67%），正常的环状结构在真皮-表皮交界处完全或部分消失（9/9，100％），中等折射率杂乱无章的粗纤维材料（8/9，89%），大量高折射率圆形细胞（9/9，100％）在真皮。
结论：RCM可以可视化NLE的主要关键诊断特征，并作为NLE的补充诊断工具。
