Abstract：
BACKGROUND: Recently, the incidence of hypertriglyceridemia-associated pancreatitis (HTG-AP) has been increasing. The pathogenesis of lipogenic pancreatitis is not fully understood. This study aimed to retrospectively analyze the laboratory data, clinical manifestations, and prognosis of patients with lipid-derived pancreatitis who received lipid purification, to explore whether lipid purification is a better treatment for acute hyperlipidemic pancreatitis.
METHODS: In this study, we enrolled five subjects diagnosed with HTG-AP at the Second Xiangya Hospital of Central South University between 2021 and 2022. We collected demographic data, medical histories, clinical manifestations, and laboratory data. All patients received routine therapy. Blood lipid purification was conducted using the double filtration plasmapheresis (DFPP) method. Plasma was separated from blood cells and purified to remove cholesterol, triglycerides, and low-density lipoprotein (LDL). SPSS was used for statistical analyses.
RESULTS: Following a single lipoprotein apheresis (LA) treatment, significant improvements in serum lipid levels were observed. Three patients achieved triglyceride levels below 5.65 mmol/L within 24 h, while the remaining 2 patients experienced reductions of 82% and 78%, respectively. The average triglyceride level decreased from 36.82 to 7.27 mmol/L, representing an 80% reduction from baseline. Total cholesterol decreased by 59% on average, and LDL levels decreased by 69%. Statistically significant differences were observed in triglyceride and cholesterol levels before and after treatment. Four patients exhibited increased HDL levels posttreatment, while 1 patient showed a decrease. The average HDL/TC level was 21% higher after treatment.
CONCLUSIONS: LA in HTG-AP effectively improves clinical symptoms, rapidly lowers lipid levels, and achieves good therapeutic outcomes.
METHODS: In this study, we enrolled five subjects diagnosed with HTG-AP at the Second Xiangya Hospital of Central South University between 2021 and 2022. We collected demographic data, medical histories, clinical manifestations, and laboratory data. All patients received routine therapy. Blood lipid purification was conducted using the double filtration plasmapheresis (DFPP) method. Plasma was separated from blood cells and purified to remove cholesterol, triglycerides, and low-density lipoprotein (LDL). SPSS was used for statistical analyses.
RESULTS: Following a single lipoprotein apheresis (LA) treatment, significant improvements in serum lipid levels were observed. Three patients achieved triglyceride levels below 5.65 mmol/L within 24 h, while the remaining 2 patients experienced reductions of 82% and 78%, respectively. The average triglyceride level decreased from 36.82 to 7.27 mmol/L, representing an 80% reduction from baseline. Total cholesterol decreased by 59% on average, and LDL levels decreased by 69%. Statistically significant differences were observed in triglyceride and cholesterol levels before and after treatment. Four patients exhibited increased HDL levels posttreatment, while 1 patient showed a decrease. The average HDL/TC level was 21% higher after treatment.
CONCLUSIONS: LA in HTG-AP effectively improves clinical symptoms, rapidly lowers lipid levels, and achieves good therapeutic outcomes.
摘要：
背景：最近，高甘油三酯血症相关胰腺炎(HTG-AP)的发病率一直在增加.脂肪源性胰腺炎的发病机制尚不完全清楚。本研究旨在回顾性分析实验室数据，临床表现，接受脂质净化的脂源性胰腺炎患者的预后，探讨脂质净化治疗急性高脂血症性胰腺炎是否较好。
方法：在本研究中，我们在2021年至2022年期间在中南大学湘雅二医院招募了5名诊断为HTG-AP的受试者。我们收集了人口统计数据,病史,临床表现，实验室数据。所有患者均接受常规治疗。使用双重过滤血浆置换(DFPP)方法进行血脂纯化。将血浆从血细胞中分离并纯化以去除胆固醇，甘油三酯，低密度脂蛋白（LDL）。采用SPSS进行统计分析。
结果：单脂蛋白单采（LA）治疗后，观察到血清脂质水平显着改善。3例患者在24小时内达到甘油三酯水平低于5.65mmol/L，而其余两名患者则减少了82%和78%，分别。平均甘油三酯水平从36.82下降到7.27mmol/L,代表比基线减少80%。总胆固醇平均下降了59%,LDL水平下降了69%。治疗前后甘油三酯和胆固醇水平差异有统计学意义。四名患者治疗后HDL水平升高，而一名患者表现出下降。治疗后HDL/TC平均升高21%。
结论：LA在HTG-AP中有效改善临床症状，迅速降低血脂水平，并取得良好的治疗效果。
方法：在本研究中，我们在2021年至2022年期间在中南大学湘雅二医院招募了5名诊断为HTG-AP的受试者。我们收集了人口统计数据,病史,临床表现，实验室数据。所有患者均接受常规治疗。使用双重过滤血浆置换(DFPP)方法进行血脂纯化。将血浆从血细胞中分离并纯化以去除胆固醇，甘油三酯，低密度脂蛋白（LDL）。采用SPSS进行统计分析。
结果：单脂蛋白单采（LA）治疗后，观察到血清脂质水平显着改善。3例患者在24小时内达到甘油三酯水平低于5.65mmol/L，而其余两名患者则减少了82%和78%，分别。平均甘油三酯水平从36.82下降到7.27mmol/L,代表比基线减少80%。总胆固醇平均下降了59%,LDL水平下降了69%。治疗前后甘油三酯和胆固醇水平差异有统计学意义。四名患者治疗后HDL水平升高，而一名患者表现出下降。治疗后HDL/TC平均升高21%。
结论：LA在HTG-AP中有效改善临床症状，迅速降低血脂水平，并取得良好的治疗效果。
