Abstract：
UNASSIGNED: Exosomes, a type of extracellular vesicles, are effective tools for delivering small-molecule drugs and biological therapeutics into cells and tissues. Surface modifications with targeting ligands ensure precise delivery to specific cells, minimizing accumulation in healthy organs and reducing the side effects. This is a rapidly growing area in drug delivery research and this review aims to comprehensively discuss the recent advances in the field.
UNASSIGNED: Recent studies have presented compelling evidence supporting the application of exosomes as efficient delivery vehicles that escape endosome trapping, achieving effective in vivo delivery in animal models. This review provides a systemic discussion on the exosome-based delivery technology, with topics covering exosome purification, surface modification, and targeted delivery of various cargos ranging from siRNAs, miRNAs, and proteins, to small molecule drugs.
UNASSIGNED: Exosome-based gene and drug delivery has low toxicity and low immunogenicity. Surface modifications of the exosomes can effectively avoid endosome trapping and increase delivery efficiency. This exciting technology can be applied to improve the treatments for a wide variety of diseases.
UNASSIGNED: Recent studies have presented compelling evidence supporting the application of exosomes as efficient delivery vehicles that escape endosome trapping, achieving effective in vivo delivery in animal models. This review provides a systemic discussion on the exosome-based delivery technology, with topics covering exosome purification, surface modification, and targeted delivery of various cargos ranging from siRNAs, miRNAs, and proteins, to small molecule drugs.
UNASSIGNED: Exosome-based gene and drug delivery has low toxicity and low immunogenicity. Surface modifications of the exosomes can effectively avoid endosome trapping and increase delivery efficiency. This exciting technology can be applied to improve the treatments for a wide variety of diseases.
摘要：
■外泌体，一种细胞外囊泡，是将小分子药物和生物治疗剂递送到细胞和组织中的有效工具。具有靶向配体的表面修饰可确保精确递送至特定细胞，减少在健康器官的积累和减少副作用。这是药物递送研究中快速增长的领域，这篇综述旨在全面讨论该领域的最新进展。
■最近的研究提供了令人信服的证据支持外泌体作为有效的传递载体，逃避内体捕获，在动物模型中实现有效的体内递送。这篇综述对基于外泌体的递送技术进行了系统的讨论，主题涵盖外泌体净化，表面改性,靶向递送各种货物，包括siRNA，miRNA,和蛋白质，小分子药物。
■基于外泌体的基因和药物递送具有低毒性和低免疫原性。外泌体的表面修饰可以有效地避免内体捕获并提高递送效率。这项令人兴奋的技术可用于改善各种疾病的治疗方法。
■最近的研究提供了令人信服的证据支持外泌体作为有效的传递载体，逃避内体捕获，在动物模型中实现有效的体内递送。这篇综述对基于外泌体的递送技术进行了系统的讨论，主题涵盖外泌体净化，表面改性,靶向递送各种货物，包括siRNA，miRNA,和蛋白质，小分子药物。
■基于外泌体的基因和药物递送具有低毒性和低免疫原性。外泌体的表面修饰可以有效地避免内体捕获并提高递送效率。这项令人兴奋的技术可用于改善各种疾病的治疗方法。
