UNASSIGNED: Recent studies have presented compelling evidence supporting the application of exosomes as efficient delivery vehicles that escape endosome trapping, achieving effective in vivo delivery in animal models. This review provides a systemic discussion on the exosome-based delivery technology, with topics covering exosome purification, surface modification, and targeted delivery of various cargos ranging from siRNAs, miRNAs, and proteins, to small molecule drugs.
UNASSIGNED: Exosome-based gene and drug delivery has low toxicity and low immunogenicity. Surface modifications of the exosomes can effectively avoid endosome trapping and increase delivery efficiency. This exciting technology can be applied to improve the treatments for a wide variety of diseases.
■最近的研究提供了令人信服的证据支持外泌体作为有效的传递载体,逃避内体捕获,在动物模型中实现有效的体内递送。这篇综述对基于外泌体的递送技术进行了系统的讨论,主题涵盖外泌体净化,表面改性,靶向递送各种货物,包括siRNA,miRNA,和蛋白质,小分子药物。
■基于外泌体的基因和药物递送具有低毒性和低免疫原性。外泌体的表面修饰可以有效地避免内体捕获并提高递送效率。这项令人兴奋的技术可用于改善各种疾病的治疗方法。