PDF(Pubmed)
Abstract：
The Amazon biome is home to many scorpion species, with around two hundred identified in the region. Of these, forty-eight species have been reported in Brazil so far and six of them are of medical importance: Tityus apiacas, T. metuendus, T. obscurus, T. raquelae, T. silvestris, and T. strandi. Three non-medically important species have also been studied: Opisthanthuscayaporum, Brotheas amazonicus and Rhopalurus laticauda. The venom of the scorpion T. obscurus is the most studied, followed by O. cayaporum. We aim to update the study of these Amazonian scorpion species. We will explore the harmful and beneficial properties of scorpion venom toxins and how they could be applied in drug development. This systematic review will focus on collecting and analyzing venoms from scorpions in Brazil. Only papers on Amazonian scorpion venom studies published between 2001 and 2021 (scientific articles, theses, and dissertations) were selected, based on the lists of scorpions available in the literature. Species found in the Amazon but not confirmed to be Brazilian were omitted from the review. Theses and dissertations were chosen over their derived articles. We found 42 eligible studies (13 theses, 27 articles and 2 patents) out of 17,950 studies and a basic statistical analysis was performed. The literature showed that T. obscurus was the most studied venom with 28 publications, followed by O. cayaporum with seven articles, B. amazonicus with four articles, T. metuendus with two article and R. laticauda with one article. No publication on the characterization of T. silvestris and T. apiacas venoms were found during the reviewed period, only the clinical aspects were covered. There is still much to be explored despite the increasing number of studies conducted in recent years. Amazonian scorpions have promising potential for pharmaceutical and clinical applications.
摘要：
亚马逊生物群落是许多蝎子物种的家园，该地区大约有200人被确认。其中,到目前为止，巴西已经报道了48种，其中6种具有医学意义：泰提亚，T.Metuendus,T.黑暗，T.raquelae，T.silvestris,还有T.strandi.还研究了三个非医学上重要的物种：Opisthanthuscayaporum，亚马逊兄弟和Rhopaluruslaticauda。蝎子的毒液是研究最多的，其次是O.cayaporum.我们的目标是更新这些亚马逊蝎子物种的研究。我们将探讨蝎毒毒素的有害和有益特性，以及它们如何应用于药物开发。本系统综述将集中于收集和分析巴西蝎子的毒液。仅在2001年至2021年之间发表的有关亚马逊蝎毒研究的论文（科学文章，theses,和论文)被选中，根据文献中提供的蝎子名单。在亚马逊发现但未确认为巴西的物种在审查中被省略。论文和论文是在其派生文章中选择的。我们发现了42项符合条件的研究(13篇论文，17,950项研究中的27篇文章和2项专利），并进行了基本的统计分析。文献表明，隐士是研究最多的毒液，有28种出版物，其次是O.cayaporum，有七篇文章，B.亚马逊有四篇文章，T.metuendus有两篇文章，R.laticauda有一篇文章。在审查期间，没有发现有关T.silvestris和T.apiacas毒液特征的出版物，仅涵盖临床方面.尽管近年来进行的研究越来越多，但仍有许多需要探索的地方。亚马逊蝎子在制药和临床应用方面具有广阔的潜力。
