PDF(Pubmed)
Abstract：
Point-of-care (POC) has the capacity to support low-cost, accurate and real-time actionable diagnostic data. Microneedle sensors have received considerable attention as an emerging technique to evolve blood-based diagnostics owing to their direct and painless access to a rich source of biomarkers from interstitial fluid. This review systematically summarizes the recent innovations in microneedle sensors with a particular focus on their utility in POC diagnostics and personalized medicine. The integration of various sensing techniques, mostly electrochemical and optical sensing, has been established in diverse architectures of \"lab-on-a-microneedle\" platforms. Microneedle sensors with tailored geometries, mechanical flexibility, and biocompatibility are constructed with a variety of materials and fabrication methods. Microneedles categorized into four types: metals, inorganics, polymers, and hydrogels, have been elaborated with state-of-the-art bioengineering strategies for minimally invasive, continuous, and multiplexed sensing. Microneedle sensors have been employed to detect a wide range of biomarkers from electrolytes, metabolites, polysaccharides, nucleic acids, proteins to drugs. Insightful perspectives are outlined from biofluid, microneedles, biosensors, POC devices, and theragnostic instruments, which depict a bright future of the upcoming personalized and intelligent health management.
摘要：
定点照护(POC)有能力支持低成本、准确和实时可操作的诊断数据。微针传感器作为发展基于血液的诊断的新兴技术已经受到相当大的关注,这是由于它们直接且无痛地从间质液中获得丰富的生物标志物来源。这篇综述系统地总结了微针传感器的最新创新，特别关注它们在POC诊断和个性化医疗中的应用。各种传感技术的集成，主要是电化学和光学传感，已在“实验室在微针”平台的不同架构中建立。具有定制几何形状的微针传感器，机械灵活性,和生物相容性用多种材料和制造方法构建。微针分为四种类型：金属，无机物,聚合物，和水凝胶，已经详细阐述了最先进的微创生物工程策略，连续,和多路复用传感。微针传感器已用于检测电解质中的各种生物标志物，代谢物，多糖，核酸,蛋白质到药物。从生物流体中概述了深刻的观点，微针,生物传感器，POC设备,和治疗工具，这描绘了即将到来的个性化和智能健康管理的光明未来。
