PDF(Pubmed)
Abstract：
In this study, it was aimed to assess effects of subclinical hyperthyroidism (SH) on bone metabolism using osteoprotegerin (OPG), sclerostin, Dickkopf-1 (DKK1) and biochemical parameters. This cross-sectional prospective study included 40 patients with SH and 40 euthyroid controls. Serum OPG, sclerostin, DKK-1, type-1 procollagen, C-terminal polypeptide (CTx) and 24-hours urine N-terminal telopeptide (NTx) were measures using ELISA kit. Bone mineral density measurements were performed using dual energy X-ray absorptiometry (DEXA). Risk for 10-years hip and major fracture was estimated by Turkish version of FRAX. No significant difference was detected in age, gender, body mass index, smoking and menopause rates between SH and control groups. The risk for 10-years hip fracture and major osteoporotic fracture were estimated as 4.45% and 0.55% in SH group, respectively. The OPG levels were significantly lower in patients with SH than controls (P = 0.017). No significant difference was detected in other bone formation and degradation parameters. No significant correlation was detected between OPG level and risk for major osteoporotic fracture (P > 0.05); however, a negative correlation was detected between OPG level and risk for hip fracture (rho = 0.233; P = 0.038). Serum OPG is markedly affected in patients with SH. In addition, OPG seemed to be associated with osteoporotic fracture risk. Available data show that SH is significantly associated with risk for fracture; thus, it is important to assess risk for fracture in patients with SH.
摘要：
在这项研究中,目的是使用骨保护素（OPG）评估亚临床甲状腺功能亢进（SH）对骨代谢的影响，硬化蛋白,Dickkopf-1(DKK1)和生化参数。这项横断面前瞻性研究包括40例SH患者和40例甲状腺功能正常对照。血清OPG,硬化蛋白,DKK-1,1型前胶原,使用ELISA试剂盒测量C末端多肽（CTx）和24小时尿N末端端肽（NTx）。使用双能X射线吸收法(DEXA)进行骨矿物质密度测量。土耳其版本的FRAX估计了10年髋部和严重骨折的风险。在年龄上没有检测到显著差异，性别,身体质量指数,SH组和对照组的吸烟率和更年期率。SH组10年髋部骨折和严重骨质疏松性骨折的风险分别为4.45%和0.55%。分别。SH患者的OPG水平明显低于对照组（P=0.017）。在其他骨形成和降解参数中未检测到显着差异。OPG水平与严重骨质疏松性骨折风险无显著相关性(P>0.05);OPG水平与髋部骨折风险呈负相关(rho=0.233;P=0.038).SH患者的血清OPG受到显着影响。此外,OPG似乎与骨质疏松性骨折风险有关。现有数据表明，SH与骨折风险显着相关；因此，评估SH患者的骨折风险非常重要.
