PDF(Pubmed)
Abstract：
UNASSIGNED: Anorgasmia is a poorly understood phenomenon defined as either a lifelong or acquired consistent inability to achieve ejaculation. Despite the prevalence of anorgasmia, there is currently no established treatment for the condition.
UNASSIGNED: To report a unique case of a patient with lifelong anorgasmia who was able to achieve his first orgasm with off-label use of flibanserin.
UNASSIGNED: The present case study relies on the patient\'s self-report and a review of the relevant literature. The patient provided written informed consent.
UNASSIGNED: A 28-year-old male presented to our office with complaints of lifelong anorgasmia, without any signs of erectile dysfunction. He reported good libido and energy levels and denied any urinary symptoms or history of depression. The patient failed medical management with numerous off-label medications, including bupropion and bremelanotide. Despite having received 4 or 5 sex therapy sessions over 3 months, the patient reported that this treatment approach was not effective. Off-label use of flibanserin was then initiated, and after 28 to 32 doses over 4 weeks, he achieved his first orgasm. Notably, the patient experienced nocturia and insomnia. The follow-up International Index of Erectile Function score marginally improved by 2 points without any improvement in the overall satisfaction subdomain.
UNASSIGNED: This case highlights the challenges of managing anorgasmia and anejaculation in a young male patient. A stepwise approach involving pharmacotherapy and sex therapy was not successful. However, the off-label use of flibanserin ultimately resulted in the patient achieving his first orgasm, albeit with some side effects. Further studies are needed to evaluate the efficacy and safety of flibanserin in men for this indication.
UNASSIGNED: To report a unique case of a patient with lifelong anorgasmia who was able to achieve his first orgasm with off-label use of flibanserin.
UNASSIGNED: The present case study relies on the patient\'s self-report and a review of the relevant literature. The patient provided written informed consent.
UNASSIGNED: A 28-year-old male presented to our office with complaints of lifelong anorgasmia, without any signs of erectile dysfunction. He reported good libido and energy levels and denied any urinary symptoms or history of depression. The patient failed medical management with numerous off-label medications, including bupropion and bremelanotide. Despite having received 4 or 5 sex therapy sessions over 3 months, the patient reported that this treatment approach was not effective. Off-label use of flibanserin was then initiated, and after 28 to 32 doses over 4 weeks, he achieved his first orgasm. Notably, the patient experienced nocturia and insomnia. The follow-up International Index of Erectile Function score marginally improved by 2 points without any improvement in the overall satisfaction subdomain.
UNASSIGNED: This case highlights the challenges of managing anorgasmia and anejaculation in a young male patient. A stepwise approach involving pharmacotherapy and sex therapy was not successful. However, the off-label use of flibanserin ultimately resulted in the patient achieving his first orgasm, albeit with some side effects. Further studies are needed to evaluate the efficacy and safety of flibanserin in men for this indication.
摘要：
■性高潮是一种鲜为人知的现象，被定义为终身或获得性持续无法实现射精。尽管性高潮普遍存在，目前尚无确定的治疗方法。
■报告一个终生性高潮患者的独特病例，该患者通过标签外使用氟班色林能够达到他的第一次性高潮。
■本病例研究依赖于患者的自我报告和相关文献的回顾。患者提供书面知情同意书。
■一位28岁的男性出现在我们办公室，抱怨终生性高潮，没有任何勃起功能障碍的迹象。他报告性欲和能量水平良好，否认有任何泌尿症状或抑郁症史。该患者因使用多种标签外药物而未能通过医疗管理，包括安非他酮和bremelanotide.尽管在3个月内接受了4到5次性治疗，患者报告这种治疗方法无效.然后开始使用氟班色林，在4周内给28到32次剂量后，他第一次达到了性高潮.值得注意的是,患者出现夜尿症和失眠。随访国际勃起功能指数得分略有提高2分，总体满意度子域没有任何改善。
■这个案例突出了年轻男性患者治疗性高潮和射精的挑战。涉及药物治疗和性治疗的逐步方法不成功。然而,标签外使用氟班色林最终导致患者达到了他的第一次性高潮，尽管有一些副作用。需要进一步的研究来评估氟班色林在该适应症中的疗效和安全性。
■报告一个终生性高潮患者的独特病例，该患者通过标签外使用氟班色林能够达到他的第一次性高潮。
■本病例研究依赖于患者的自我报告和相关文献的回顾。患者提供书面知情同意书。
■一位28岁的男性出现在我们办公室，抱怨终生性高潮，没有任何勃起功能障碍的迹象。他报告性欲和能量水平良好，否认有任何泌尿症状或抑郁症史。该患者因使用多种标签外药物而未能通过医疗管理，包括安非他酮和bremelanotide.尽管在3个月内接受了4到5次性治疗，患者报告这种治疗方法无效.然后开始使用氟班色林，在4周内给28到32次剂量后，他第一次达到了性高潮.值得注意的是,患者出现夜尿症和失眠。随访国际勃起功能指数得分略有提高2分，总体满意度子域没有任何改善。
■这个案例突出了年轻男性患者治疗性高潮和射精的挑战。涉及药物治疗和性治疗的逐步方法不成功。然而,标签外使用氟班色林最终导致患者达到了他的第一次性高潮，尽管有一些副作用。需要进一步的研究来评估氟班色林在该适应症中的疗效和安全性。
