PDF(Pubmed)
Abstract：
UNASSIGNED: While exercise training (ET) programs show positive outcomes in cognition, motor function, and physical fitness in pediatric brain tumor (PBT) survivors, little is known about the optimal timing of intervention. The aim of this work was to explore the feasibility and benefits of ET based on its timing after radiotherapy.
UNASSIGNED: This retrospective analysis (ClinicalTrials.gov, NCT01944761) analyzed data based on the timing of PBT survivors\' participation in an ET program relative to their completion of radiotherapy: <2 years (n = 9), 2-5 years (n = 10), and > 5 years (n = 13). We used repeated measures analysis of variance to compare feasibility and efficacy indicators among groups, as well as correlation analysis between ET program timing postradiotherapy and preliminary treatment effects on cognition, motor function and physical fitness outcomes.
UNASSIGNED: Two to five years postradiotherapy was the optimal time period in terms of adherence (88.5%), retention (100%), and satisfaction (more fun, more enjoyable and recommend it more to other children). However, the benefits of ET program on memory recognition (r = -0.379, P = .047) and accuracy (r = -0.430, P = .032) decreased with increased time postradiotherapy. Motor function improved in all groups, with greater improvements in bilateral coordination (P = .043) earlier postradiotherapy, and in running (P = .043) later postradiotherapy. The greatest improvement in pro-rated work rate occurred in the < 2-year group (P = .008).
UNASSIGNED: Participation in an ET program should be offered as part of routine postradiotherapy care in the first 1-2 years and strongly encouraged in the first 5 years.
UNASSIGNED: This retrospective analysis (ClinicalTrials.gov, NCT01944761) analyzed data based on the timing of PBT survivors\' participation in an ET program relative to their completion of radiotherapy: <2 years (n = 9), 2-5 years (n = 10), and > 5 years (n = 13). We used repeated measures analysis of variance to compare feasibility and efficacy indicators among groups, as well as correlation analysis between ET program timing postradiotherapy and preliminary treatment effects on cognition, motor function and physical fitness outcomes.
UNASSIGNED: Two to five years postradiotherapy was the optimal time period in terms of adherence (88.5%), retention (100%), and satisfaction (more fun, more enjoyable and recommend it more to other children). However, the benefits of ET program on memory recognition (r = -0.379, P = .047) and accuracy (r = -0.430, P = .032) decreased with increased time postradiotherapy. Motor function improved in all groups, with greater improvements in bilateral coordination (P = .043) earlier postradiotherapy, and in running (P = .043) later postradiotherapy. The greatest improvement in pro-rated work rate occurred in the < 2-year group (P = .008).
UNASSIGNED: Participation in an ET program should be offered as part of routine postradiotherapy care in the first 1-2 years and strongly encouraged in the first 5 years.
摘要：
■虽然运动训练（ET）计划在认知方面显示出积极的结果，运动功能,小儿脑肿瘤（PBT）幸存者的身体素质，对干预的最佳时机知之甚少。这项工作的目的是根据放疗后的时机探索ET的可行性和益处。
■本回顾性分析(ClinicalTrials.gov，NCT01944761）根据PBT幸存者参与ET计划的时间相对于他们完成放射治疗的时间分析数据：<2年（n=9），2-5年（n=10），和>5年（n=13）。我们使用重复测量方差分析来比较各组之间的可行性和疗效指标，以及放疗后ET计划时机与初步治疗对认知的影响之间的相关性分析，运动功能和身体健康的结果。
■放疗后两到五年是依从性的最佳时间段（88.5％），保留率（100%），和满意度(更有趣，更令人愉快，并更多地推荐给其他孩子）。然而,ET程序对记忆识别(r=-0.379,P=.047)和准确性(r=-0.430,P=.032)的益处随着放疗后时间的增加而降低。所有组的运动功能都得到了改善，随着早期放疗后双边协调的改善(P=.043)，并在放疗后运行（P=.043）。按比例工作率的最大改善发生在<2年组（P=.008）。
■在最初的1-2年内，应将参与ET计划作为常规放疗后护理的一部分，并在最初的5年内大力鼓励。
■本回顾性分析(ClinicalTrials.gov，NCT01944761）根据PBT幸存者参与ET计划的时间相对于他们完成放射治疗的时间分析数据：<2年（n=9），2-5年（n=10），和>5年（n=13）。我们使用重复测量方差分析来比较各组之间的可行性和疗效指标，以及放疗后ET计划时机与初步治疗对认知的影响之间的相关性分析，运动功能和身体健康的结果。
■放疗后两到五年是依从性的最佳时间段（88.5％），保留率（100%），和满意度(更有趣，更令人愉快，并更多地推荐给其他孩子）。然而,ET程序对记忆识别(r=-0.379,P=.047)和准确性(r=-0.430,P=.032)的益处随着放疗后时间的增加而降低。所有组的运动功能都得到了改善，随着早期放疗后双边协调的改善(P=.043)，并在放疗后运行（P=.043）。按比例工作率的最大改善发生在<2年组（P=.008）。
■在最初的1-2年内，应将参与ET计划作为常规放疗后护理的一部分，并在最初的5年内大力鼓励。
