PDF(Pubmed)
Abstract：
Patients with cancer are increasingly vulnerable to infections, which may be more severe than in the general population. Improvements in rapid and timely diagnosis to optimize management are needed. We conducted a systematic literature review to determine the unmet need in diagnosing acute infections in immunocompromised patients with cancer and identified 50 eligible studies from 5188 records between 1 January 2012 and 23 June 2022. There was considerable heterogeneity in study designs and parameters, laboratory methods and definitions, and assessed outcomes, with limited evaluation of diagnostic impact on clinical outcomes. Culture remains the primary diagnostic strategy. Fewer studies employing molecular technologies exist, but emerging literature suggests that pathogen-agnostic molecular tests may add to the diagnostic armamentarium. Well-designed clinical studies using standardized methodologies are needed to better evaluate performance characteristics and clinical and economic impacts of emerging diagnostic techniques to improve patient outcomes.
摘要：
癌症患者越来越容易受到感染，这可能比普通人群更严重。需要改进快速及时的诊断以优化管理。我们进行了系统的文献综述，以确定在2012年1月1日至2022年6月23日期间诊断免疫功能低下的癌症患者急性感染的未满足的需求，并从5188个记录中确定了50个合格的研究。研究设计和参数存在相当大的异质性，实验室方法和定义，和评估的结果，对临床结果的诊断影响评估有限。文化仍然是主要的诊断策略。使用分子技术的研究较少，但新出现的文献表明，病原体不可知的分子测试可能会增加诊断性医疗设备。需要使用标准化方法进行精心设计的临床研究，以更好地评估新兴诊断技术的性能特征以及临床和经济影响，以改善患者的预后。
