Abstract：
BACKGROUND: Women with polycystic ovary syndrome (PCO) suffer from psychological difficulties like bipolar disorder. Various studies in the literature report several prevalence rates of bipolar disorder in women with PCO, while there is no systematic review in this field. So, we designed this systematic review and meta-analysis to estimate the pooled prevalence and odds of bipolar disorder in women with PCO disease.
METHODS: PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and references of the references, conference abstracts were comprehensively searched by two independent researchers. The search was done on May 1st, 2023.
RESULTS: A literature search revealed 438 records, 35 full texts were evaluated, and finally, 11 studies remained for systematic review. Totally, 73,102 women with PCO and 340,724 controls were evaluated. Among cases, 1471 had bipolar diagnosis vs. 4321 controls. The prevalence of bipolar disorder in women with PCO ranged between 0 and 27%, and the pooled prevalence was estimated as 4% (95% CI, 2-5%; I2, 99.3%, p < 0.001). The odds of bipolar disorder in women with PCO ranged between 0.98 and 8.78, and the pooled estimate was 2.06 (95% CI, 1.61-2.63) (I2, 85.6%; p < 0.001).
CONCLUSIONS: This systematic review and meta-analysis show that the pooled prevalence of bipolar disorder in women with PCO is 4%, and women with PCO are at a 2-fold higher risk of bipolar disorder.
METHODS: PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and references of the references, conference abstracts were comprehensively searched by two independent researchers. The search was done on May 1st, 2023.
RESULTS: A literature search revealed 438 records, 35 full texts were evaluated, and finally, 11 studies remained for systematic review. Totally, 73,102 women with PCO and 340,724 controls were evaluated. Among cases, 1471 had bipolar diagnosis vs. 4321 controls. The prevalence of bipolar disorder in women with PCO ranged between 0 and 27%, and the pooled prevalence was estimated as 4% (95% CI, 2-5%; I2, 99.3%, p < 0.001). The odds of bipolar disorder in women with PCO ranged between 0.98 and 8.78, and the pooled estimate was 2.06 (95% CI, 1.61-2.63) (I2, 85.6%; p < 0.001).
CONCLUSIONS: This systematic review and meta-analysis show that the pooled prevalence of bipolar disorder in women with PCO is 4%, and women with PCO are at a 2-fold higher risk of bipolar disorder.
摘要：
背景：患有多囊卵巢综合征（PCO）的女性患有双相情感障碍等心理困难。文献中的各种研究报告了患有PCO的女性中双相情感障碍的几种患病率，虽然在这一领域没有系统的审查。所以,我们设计了本系统综述和荟萃分析,以评估PCO疾病女性中双相情感障碍的合并患病率和几率.
方法：PubMed，Scopus,EMBASE,WebofScience,谷歌学者，和参考文献的参考文献，会议摘要由两名独立研究人员进行了全面搜索。搜索是在5月1日完成的，2023年。
结果：文献检索显示438条记录，对35篇全文进行了评估，最后，11项研究仍有待系统评价。完全正确,评估了73,102名PCO女性和340,724名对照。在案件中，1471有双相诊断vs.4321控制。PCO女性的双相情感障碍患病率介于0％至27％之间，合并患病率估计为4%(95%CI，2-5%；I2，99.3%，p<0.001)。PCO女性患者发生双相情感障碍的几率介于0.98和8.78之间，合并估计值为2.06（95％CI，1.61-2.63）（I2，85.6％；p<0.001）。
结论：这项系统评价和荟萃分析显示，患有PCO的女性中双相情感障碍的合并患病率为4％，患有PCO的女性患双相情感障碍的风险高2倍。
方法：PubMed，Scopus,EMBASE,WebofScience,谷歌学者，和参考文献的参考文献，会议摘要由两名独立研究人员进行了全面搜索。搜索是在5月1日完成的，2023年。
结果：文献检索显示438条记录，对35篇全文进行了评估，最后，11项研究仍有待系统评价。完全正确,评估了73,102名PCO女性和340,724名对照。在案件中，1471有双相诊断vs.4321控制。PCO女性的双相情感障碍患病率介于0％至27％之间，合并患病率估计为4%(95%CI，2-5%；I2，99.3%，p<0.001)。PCO女性患者发生双相情感障碍的几率介于0.98和8.78之间，合并估计值为2.06（95％CI，1.61-2.63）（I2，85.6％；p<0.001）。
结论：这项系统评价和荟萃分析显示，患有PCO的女性中双相情感障碍的合并患病率为4％，患有PCO的女性患双相情感障碍的风险高2倍。
