Our review includes 11 rodent studies, seven fish studies, and five human studies. Evidence from animal studies suggests that triclosan decreases the diversity of the microbiome, although only one epidemiologic study agreed. Most studies suggest that triclosan alters the microbial community beta diversity, but disagree on which taxa contributed to compositional differences. Taxa in the Bacteroidetes, Firmicutes, and Proteobacteria may be more influenced by triclosan than those in other phyla. Studies on triclosan and the microbiome were scarce and were inconclusive as to the effects of triclosan on the microbiome. Additional research is needed to clarify windows of heightened susceptibility of the microbiome to triclosan. We recommend guidelines for future microbiome research in environmental health to increase comparability across studies.
结果:我们的综述包括11项啮齿动物研究,七项鱼类研究,和五项人体研究。来自动物研究的证据表明,三氯生降低了微生物组的多样性,尽管只有一项流行病学研究同意。大多数研究表明三氯生改变微生物群落β多样性,但不同意哪个类群导致了成分差异。拟杆菌中的类群,Firmicutes,与其他门相比,三氯生对变形杆菌的影响可能更大。关于三氯生和微生物组的研究很少,关于三氯生对微生物组的影响尚无定论。需要进一步的研究来澄清微生物组对三氯生的敏感性增加的窗口。我们推荐未来环境健康微生物组研究的指南,以增加研究之间的可比性。