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Abstract：
Schizophrenia (SCZ) is a psychotic disorder with an unknown pathogenesis accompanied by varying degrees of cognitive deficits. Recent studies have shown that immune dysregulation plays an important role in developing symptoms and cognitive deficits in SCZ. This study aimed to determine the complete blood count (CBC), including white blood cells, neutrophils, monocytes, lymphocytes, platelets, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR), in patients with SCZ and explore their correlations with SCZ symptom dimensions and cognitive function.
Seventy-four patients with SCZ and 57 age- and sex-matched healthy controls with available demographic and clinical information were recruited for this study. Blood samples were collected, and symptom dimensions and cognitive function were evaluated using the Positive and Negative Syndrome Scale (PANSS) and MATRICS Consensus Cognitive Battery (MCCB) separately.
Our results demonstrate that SCZ patients showed higher monocyte counts, PLR, MLR, and worse performance in the total MCCB than healthy controls. Neutrophil and lymphocyte counts and NLR were positively related to symptom severity and negatively related to depressive symptoms. White blood cell (WBC) count, monocyte count, and MLR were positively correlated with cognitive performance in patients with SCZ.
In summary, this study suggests that cognitive deficits and symptom severity in patients were associated with dysregulation of immunity. Moreover, we found that WBC could be used as a marker for symptom severity and cognitive deficits in SCZ and that neutrophils are more closely related to the former and monocytes to the latter. We hope that clinicians will pay more attention to dysregulated immunity in patients with SCZ in the future.
Seventy-four patients with SCZ and 57 age- and sex-matched healthy controls with available demographic and clinical information were recruited for this study. Blood samples were collected, and symptom dimensions and cognitive function were evaluated using the Positive and Negative Syndrome Scale (PANSS) and MATRICS Consensus Cognitive Battery (MCCB) separately.
Our results demonstrate that SCZ patients showed higher monocyte counts, PLR, MLR, and worse performance in the total MCCB than healthy controls. Neutrophil and lymphocyte counts and NLR were positively related to symptom severity and negatively related to depressive symptoms. White blood cell (WBC) count, monocyte count, and MLR were positively correlated with cognitive performance in patients with SCZ.
In summary, this study suggests that cognitive deficits and symptom severity in patients were associated with dysregulation of immunity. Moreover, we found that WBC could be used as a marker for symptom severity and cognitive deficits in SCZ and that neutrophils are more closely related to the former and monocytes to the latter. We hope that clinicians will pay more attention to dysregulated immunity in patients with SCZ in the future.
摘要：
背景：精神分裂症（SCZ）是一种发病机制未知的精神病，伴有不同程度的认知缺陷。最近的研究表明，免疫失调在SCZ症状和认知缺陷的发展中起重要作用。本研究旨在确定全血细胞计数（CBC），包括白细胞,中性粒细胞，单核细胞,淋巴细胞，血小板,中性粒细胞-淋巴细胞比率（NLR），血小板-淋巴细胞比率（PLR），和单核细胞-淋巴细胞比率（MLR），并探讨其与SCZ症状维度及认知功能的相关性。
方法：本研究招募了74名SCZ患者和57名年龄和性别匹配的健康对照，并提供了人口统计学和临床信息。采集血样,分别使用阳性和阴性综合征量表（PANSS）和MATRICS共识认知量表（MCCB）评估症状维度和认知功能。
结果：我们的结果表明，SCZ患者的单核细胞计数更高，PLR,MLR,与健康对照组相比，整体MCCB的表现更差。中性粒细胞和淋巴细胞计数及NLR与症状严重程度呈正相干，与抑郁症状呈负相干。白细胞（WBC）计数，单核细胞计数,和MLR与SCZ患者的认知能力呈正相关。
结论：总之，这项研究表明，患者的认知缺陷和症状严重程度与免疫失调有关。此外，我们发现WBC可作为SCZ症状严重程度和认知缺陷的标志物,中性粒细胞与前者更密切相关,单核细胞与后者更密切相关.我们希望未来临床医生会更加关注SCZ患者的免疫失调。
方法：本研究招募了74名SCZ患者和57名年龄和性别匹配的健康对照，并提供了人口统计学和临床信息。采集血样,分别使用阳性和阴性综合征量表（PANSS）和MATRICS共识认知量表（MCCB）评估症状维度和认知功能。
结果：我们的结果表明，SCZ患者的单核细胞计数更高，PLR,MLR,与健康对照组相比，整体MCCB的表现更差。中性粒细胞和淋巴细胞计数及NLR与症状严重程度呈正相干，与抑郁症状呈负相干。白细胞（WBC）计数，单核细胞计数,和MLR与SCZ患者的认知能力呈正相关。
结论：总之，这项研究表明，患者的认知缺陷和症状严重程度与免疫失调有关。此外，我们发现WBC可作为SCZ症状严重程度和认知缺陷的标志物,中性粒细胞与前者更密切相关,单核细胞与后者更密切相关.我们希望未来临床医生会更加关注SCZ患者的免疫失调。
