Abstract：
Perceiving and modulating emotions is vital for cognitive function and is often impaired in neuropsychiatric conditions. Current tools for evaluating emotional dysregulation suffer from subjectivity and lack of precision, especially when it comes to understanding emotion from a regulatory or control-based perspective. To address these limitations, this study leverages an advanced methodology known as functional brain controllability analysis. We simultaneously recorded electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data from 17 healthy subjects engaged in emotion processing and regulation tasks. We then employed a novel EEG/fMRI integration technique to reconstruct cortical activity in a high spatiotemporal resolution manner. Subsequently, we conducted functional brain controllability analysis to explore the neural network control patterns underlying different emotion conditions. Our findings demonstrated that the dorsolateral and ventrolateral prefrontal cortex exhibited increased controllability during the processing and regulation of negative emotions compared to processing of neutral emotion. Besides, the anterior cingulate cortex was notably more active in managing negative emotion than in either controlling neutral emotion or regulating negative emotion. Finally, the posterior parietal cortex emerged as a central network controller for the regulation of negative emotion. This study offers valuable insights into the cortical control mechanisms that support emotion perception and regulation.
摘要：
感知和调节情绪对于认知功能至关重要，并且在神经精神疾病中经常受损。当前评估情绪失调的工具存在主观性和缺乏准确性，尤其是当它涉及到理解情绪从监管或基于控制的角度。为了解决这些限制，这项研究利用了一种先进的方法，称为脑功能可控性分析。我们同时记录了17名从事情绪处理和调节任务的健康受试者的脑电图（EEG）和功能磁共振成像（fMRI）数据。然后，我们采用了一种新颖的EEG/fMRI集成技术，以高时空分辨率方式重建皮质活动。随后，我们进行了脑功能可控性分析，以探索不同情绪条件下的神经网络控制模式。我们的发现表明，与中性情绪的处理相比，背外侧和腹外侧前额叶皮层在负面情绪的处理和调节过程中表现出更高的可控性。此外,前扣带回皮质在管理负面情绪方面明显比在控制中性情绪或调节负面情绪方面更活跃。最后,后顶叶皮层成为调节负面情绪的中央网络控制器。这项研究为支持情绪感知和调节的皮层控制机制提供了有价值的见解。
