PDF(Pubmed)
Abstract：
The present study aimed to investigate the association between the expression profiles of long non-coding RNAs (lncRNAs) and the clinical characteristics or prognosis of patients with nasopharyngeal carcinoma (NPC). The findings presented in the present review may provide novel strategies for the prevention and treatment of NPC. For the analyses, medical databases, including PubMed, Web of Science and Cochrane library were searched using specific search terms, search strategies and screening strategies. Endnote X9 document management software was then employed to extract documents from January, 2010 to May, 2023. Data were extracted following the prescribed standards. Review Manager 5.4 and STATA 12.0 data analysis software were used for data analysis. A total of 490 publications were analyzed for inclusion. In total, 29 publications, composed of 24 studies with upregulated lncRNAs and 5 studies with downregulated lncRNAs, were included in the final analysis. The analysis revealed that the upregulation of lncRNAs was significantly associated with T stage, N stage and clinical stage, as well as with the overall survival (OS) and disease-free survival (DFS) of patients with NPC (P<0.05). However, there was no significant association between the upregulated lncRNAs and sex, M stage or relapse-free survival (RFS) (P>0.05). On the other hand, the suppression of lncRNA expression was significantly associated with N stage, M stage, clinical stage and the OS of patients with NPC (P<0.05), but not with T stage and RFS (P>0.05). Taken together, the present review demonstrates that the up- and downregulation of different lncRNAs was associated with an advanced clinical stage and a shorter OS of patients with NPC. Therefore, lncRNAs may serve as potential prognostic factors in NPC.
摘要：
本研究旨在探讨长链非编码RNA（lncRNAs）的表达谱与鼻咽癌（NPC）患者的临床特征和预后之间的关系。本综述的发现可能为NPC的预防和治疗提供新的策略。对于分析，医疗数据库,包括PubMed,使用特定的搜索词搜索了WebofScience和Cochrane图书馆，搜索策略和筛查策略。然后使用EndnoteX9文档管理软件从1月开始提取文档，2010年5月,2023年。按照规定的标准提取数据。使用ReviewManager5.4和STATA12.0数据分析软件进行数据分析。对总共490篇出版物进行了纳入分析。总的来说,29份出版物由24项上调lncRNAs的研究和5项下调lncRNAs的研究组成，包括在最终分析中。分析显示lncRNAs的上调与T分期显著相关,N分期和临床分期，NPC患者的总生存期（OS）和无病生存期（DFS）（P<0.05）。然而,上调的lncRNAs和性别之间没有显著关联，M期或无复发生存期(RFS)(P>0.05)。另一方面,lncRNA表达的抑制与N期显著相关，M阶段,NPC患者的临床分期和OS（P<0.05），但与T分期和RFS无关(P>0.05)。一起来看,本综述表明,不同lncRNAs的上调和下调与NPC患者的晚期临床阶段和较短的OS相关.因此,lncRNAs可能是鼻咽癌的潜在预后因素。
