PDF(Pubmed)
Abstract：
OBJECTIVE: Polycystic ovary syndrome (PCOS) is identified as the most common endocrine disorder in reproductive-aged women, and symptoms of PCOS appear during the early pubertal age. There is a gap in knowledge in recognizing the status of gingival inflammation/periodontal destruction and high-sensitivity C-reactive protein levels (hsCRP) in adolescents versus adults with PCOS. This study aimed to observe the impact of PCOS on periodontal status and systemic inflammation in adolescents and compared them with adults with PCOS.
METHODS: A total of 100 newly diagnosed female subjects with PCOS were enrolled into two groups: adolescents (11-19 years, n = 50) and adult females (20-40 years, n = 50). Periodontal parameters, anthropometric parameters, PCOS phenotype, hirsutism score, and serum hsCRP levels were recorded.
RESULTS: High levels of mean hsCRP, gingival index, and bleeding on probing % were observed in adolescent and adult PCOS groups, though nonsignificant between the groups (p > 0.05). Significantly more sites with probing pocket depth 3-4 mm, higher mean clinical attachment level (CAL) and sites with CAL 1-2 mm, and high frequency of patients (n = 11) with periodontitis (stage 1) were observed in adults with PCOS compared to adolescents (p ≤ 0.05). Similar and predominant prevalence of PCOS phenotype A (66%) and moderate hirsutism (46% adolescents vs. 58% adults) were observed in both groups.
CONCLUSIONS: Similar levels of hsCRP and periodontal inflammation were found in adolescents and adults with PCOS. More periodontal tissue destruction was observed in adults with PCOS as compared to adolescents with PCOS.
METHODS: A total of 100 newly diagnosed female subjects with PCOS were enrolled into two groups: adolescents (11-19 years, n = 50) and adult females (20-40 years, n = 50). Periodontal parameters, anthropometric parameters, PCOS phenotype, hirsutism score, and serum hsCRP levels were recorded.
RESULTS: High levels of mean hsCRP, gingival index, and bleeding on probing % were observed in adolescent and adult PCOS groups, though nonsignificant between the groups (p > 0.05). Significantly more sites with probing pocket depth 3-4 mm, higher mean clinical attachment level (CAL) and sites with CAL 1-2 mm, and high frequency of patients (n = 11) with periodontitis (stage 1) were observed in adults with PCOS compared to adolescents (p ≤ 0.05). Similar and predominant prevalence of PCOS phenotype A (66%) and moderate hirsutism (46% adolescents vs. 58% adults) were observed in both groups.
CONCLUSIONS: Similar levels of hsCRP and periodontal inflammation were found in adolescents and adults with PCOS. More periodontal tissue destruction was observed in adults with PCOS as compared to adolescents with PCOS.
摘要：
目的：多囊卵巢综合征（PCOS）是育龄期妇女最常见的内分泌疾病，PCOS的症状出现在青春期早期。与PCOS成人相比，在认识青少年牙龈炎症/牙周破坏和高敏C反应蛋白水平（hsCRP）的知识方面存在差距。本研究旨在观察PCOS对青少年牙周状态和全身炎症的影响，并与成人PCOS患者进行比较。
方法：将100名新诊断的PCOS女性受试者纳入两组：青少年（11-19岁，n=50),和成年女性（20-40岁，n=50)。牙周参数,人体测量参数,PCOS表型,记录多毛症评分和血清hsCRP水平。
结果：平均hsCRP水平高，GI,在青少年和成人PCOS组中观察到BOP%，虽然组间无显著性差异(p>0.05)。明显更多的地点与PPD3-4毫米，较高的平均CAL和具有CAL1-2mm的站点，与青少年相比，成人PCOS患者（n=11）牙周炎（1期）的频率较高（p≤0.05）。在两组中观察到PCOS表型A（66％）和中度多毛症（46％的青少年对58％的成年人）的相似和主要患病率。
结论：在患有PCOS的青少年和成人中，hsCRP和牙周炎症水平相似。与患有PCOS的青少年相比，患有PCOS的成人中观察到更多的牙周组织破坏。
方法：将100名新诊断的PCOS女性受试者纳入两组：青少年（11-19岁，n=50),和成年女性（20-40岁，n=50)。牙周参数,人体测量参数,PCOS表型,记录多毛症评分和血清hsCRP水平。
结果：平均hsCRP水平高，GI,在青少年和成人PCOS组中观察到BOP%，虽然组间无显著性差异(p>0.05)。明显更多的地点与PPD3-4毫米，较高的平均CAL和具有CAL1-2mm的站点，与青少年相比，成人PCOS患者（n=11）牙周炎（1期）的频率较高（p≤0.05）。在两组中观察到PCOS表型A（66％）和中度多毛症（46％的青少年对58％的成年人）的相似和主要患病率。
结论：在患有PCOS的青少年和成人中，hsCRP和牙周炎症水平相似。与患有PCOS的青少年相比，患有PCOS的成人中观察到更多的牙周组织破坏。
