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Abstract：
Medullary thyroid cancer (MTC) represents a small proportion of thyroid cancers. In MTC, melanin production is extremely uncommon. Few case reports have documented this rare variant, and follow-up on these cases has been very limited. Our case studies a 51-year-old female who initially presented with goiter. This tumor recurred multiple times despite surgery with rapid growth and poor response to radiotherapy. Microscopic examination showed high-grade malignant neoplasm with lymphocytic differentiation. Immunohistochemical studies were diffusely positive for S100, SOX10, and Melan-A. Histology confirmed melanocytic medullary carcinoma that had undergone a high-grade transformation with loss of epithelial and neuroendocrine expression. Due to the scarcity and rarity of this subtype, further evaluation and case studies are needed for further categorization and prognostication.
摘要：
甲状腺髓样癌（MTC）占甲状腺癌的一小部分。在MTC中,黑色素的产生是非常罕见的。很少有病例报告记录了这种罕见的变异，对这些案件的后续行动非常有限。我们的案例研究了一名最初患有甲状腺肿的51岁女性。尽管手术生长迅速且对放射疗法的反应较差，但该肿瘤仍多次复发。显微镜检查显示高度恶性肿瘤伴淋巴细胞分化。免疫组织化学研究对S100，SOX10和Melan-A呈弥漫性阳性。组织学证实，黑素细胞髓样癌经历了高度转化，上皮和神经内分泌表达丧失。由于这种亚型的稀缺性和稀有性，需要进一步的评估和案例研究，以进一步分类和预测。
