Abstract：
Legionellosis is a disease caused by the bacterium Legionella that most commonly presents as Legionnaires\' disease (LD), a severe form of pneumonia. From 2015 to 2019, an average of 438 LD cases per year were reported in Canada. However, it is believed that the actual number of cases is much higher, since LD may be underdiagnosed and underreported. The purpose of this study was to develop an estimate of the true incidence of illnesses, hospitalizations, and deaths associated with LD in Canada. Values were derived using a stochastic model, based on Canadian surveillance data from 2015 to 2019, which were scaled up to account for underdiagnosis and underreporting. Overall, there were an estimated 1,113 (90% CrI: 737-1,730) illnesses, 1,008 (90% CrI: 271-2,244) hospitalizations, and 34 (90% CrI: 4-86) deaths due to domestically acquired waterborne LD annually in Canada from 2015 to 2019. It was further estimated that only 36% of illnesses and 39% of hospitalizations and deaths were captured in surveillance, and that 22% of illnesses were caused by Legionella serogroups and species other than Legionella pneumophila serogroup 1 (non-Lp1). This study highlights the true burden and areas for improvement in Canada\'s surveillance and detection of LD.
摘要：
军团菌病是由军团菌引起的疾病，最常表现为军团菌病（LD），一种严重的肺炎.从2015年到2019年，加拿大平均每年报告438例LD病例。然而,据认为，实际案件数量要高得多，因为LD可能被低估和低估。这项研究的目的是估计疾病的真实发生率，住院治疗,以及与加拿大LD有关的死亡。值是使用随机模型得出的，基于2015年至2019年的加拿大监测数据，这些数据被扩大以考虑诊断不足和报告不足。总的来说,估计有1,113例(90%CrI:737-1,730例)疾病，1,008（90％CrI：271-2,244）住院，从2015年到2019年，加拿大每年有34例（90％CrI：4-86）由于国内获得的水性LD而死亡。进一步估计，只有36％的疾病和39％的住院和死亡被捕获在监测中，22％的疾病是由军团菌血清群和除嗜肺军团菌血清群1（非Lp1）以外的其他物种引起的。这项研究强调了加拿大对LD的监测和检测的真正负担和需要改进的地方。
