PDF(Pubmed)
Abstract：
Osteomyelitis is a bone disease caused by bacteria that can damage bone. Raman handheld spectroscopy has emerged as a promising diagnostic tool for detecting bone infection and can be used intraoperatively during surgical procedures. This study involved 120 bone samples from 40 patients, with 80 samples infected with either Staphylococcus aureus or Staphylococcus epidermidis. Raman handheld spectroscopy demonstrated successful differentiation between healthy and infected bone samples and between the two types of bacterial pathogens. Raman handheld spectroscopy appears to be a promising diagnostic tool in bone infection and holds the potential to overcome many of the shortcomings of traditional diagnostic procedures. Further research, however, is required to confirm its diagnostic capabilities and consider other factors, such as the limit of pathogen detection and optimal calibration standards.
摘要：
骨髓炎是一种由细菌引起的骨骼疾病，可以损害骨骼。拉曼手持光谱法已经成为用于检测骨感染的有前途的诊断工具,并且可以在外科手术期间在术中使用。这项研究涉及来自40名患者的120个骨骼样本，有80个样本感染了金黄色葡萄球菌或表皮葡萄球菌。拉曼手持光谱法证明了健康和感染骨样品之间以及两种类型的细菌病原体之间的成功区分。拉曼手持光谱法似乎是骨感染的有前途的诊断工具，并且具有克服传统诊断程序的许多缺点的潜力。进一步研究,然而,需要确认其诊断能力并考虑其他因素，如病原体检测的极限和最佳校准标准。
