PDF(Pubmed)
Abstract：
Pre-eclampsia (PE) continues to be a leading cause of maternal and fetal mortality and morbidity. While substantial progress has been made in understanding the pathomechanisms of PE, the pathophysiology of the disease is still not fully understood. While the \"two-stage model\" of the development of PE is the most widely accepted theory, stating that the placenta is the main source of the disease, there are some other pathophysiological models of PE. Among these other theories, the one considering heart dysfunction as serving as the primary cause of PE seems to be gaining increasing prominence. In this review, we aim to elucidate these two divergent concepts concerning the development of PE. Despite some differences in their proposed pathomechanisms, both theories share vital pathophysiological elements in common. A central and critical component in both models is impaired placental perfusion, which appears to be a crucial phenomenon in PE. A comprehensive understanding of the different pathomechanisms involved in PE may be helpful in clinical practice, prompting a more individual approach to care of patients with PE.
摘要：
先兆子痫（PE）仍然是孕产妇和胎儿死亡率和发病率的主要原因。虽然在理解PE的发病机制方面取得了实质性进展，该疾病的病理生理学仍未完全了解。虽然体育发展的“两阶段模型”是最广泛接受的理论，说明胎盘是疾病的主要来源，还有一些其他的PE病理生理模型。在这些其他理论中，认为心功能障碍是导致PE的主要原因的人似乎越来越受到重视。在这次审查中,我们旨在阐明这两个关于体育发展的不同概念。尽管他们提出的病理机制存在一些差异，这两种理论具有共同的重要病理生理因素。两个模型中的一个重要组成部分是胎盘灌注受损，这似乎是体育中的一个重要现象。全面了解PE的不同病理机制可能有助于临床实践。促使对PE患者采取更个性化的护理方法。
