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Abstract：
The major histocompatibility complexes of vertebrates play a key role in the immune response. Antigen-presenting cells are loaded on MHC I molecules, which mainly present endogenous antigens; when MHC I presents exogenous antigens, this is called cross-presentation. The discovery of cross-presentation provides an important theoretical basis for the study of exogenous antigens. Cross-presentation is a complex process in which MHC I molecules present antigens to the cell surface to activate CD8+ T lymphocytes. The process of cross-representation includes many components, and this article briefly outlines the origins and development of MHC molecules, gene structures, functions, and their classical presentation pathways. The cross-presentation pathways of MHC I molecules, the cell lines that support cross-presentation, and the mechanisms of MHC I molecular transporting are all reviewed. After more than 40 years of research, the specific mechanism of cross-presentation is still unclear. In this paper, we summarize cross-presentation and anticipate the research and development prospects for cross-presentation.
摘要：
脊椎动物的主要组织相容性复合物在免疫应答中起关键作用。抗原呈递细胞负载在MHCI分子上，主要呈递内源性抗原；当MHCI呈递外源性抗原时，这叫做交叉陈述。交叉呈递的发现为外源抗原的研究提供了重要的理论依据。交叉呈递是一个复杂的过程，其中MHCI分子将抗原呈递到细胞表面以激活CD8+T淋巴细胞。交叉表示的过程包括许多组件，本文简要概述了MHC分子的起源和发展，基因结构，功能,以及他们经典的演讲途径。MHCI分子的交叉呈递途径，支持交叉表达的细胞系，并对MHCI分子转运机制进行了综述。经过40多年的研究,交叉呈现的具体机制尚不清楚.在本文中,我们总结了交叉演示，并展望了交叉演示的研究和发展前景。
