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Abstract：
B-cell receptor (BCR) is a B cell hallmark surface complex regulating multiple cellular processes in normal as well as malignant B cells. Igα (CD79a)/Igβ (CD79b) are essential components of BCR that are indispensable for its functionality, signal initiation, and signal transduction. CD79a/CD79b-mediated BCR signaling is required for the survival of normal as well as malignant B cells via a wide signaling network. Recent studies identified the great complexity of this signaling network and revealed the emerging role of CD79a/CD79b in signal integration. In this review, we have focused on functional features of CD79a/CD79b, summarized signaling consequences of CD79a/CD79b post-translational modifications, and highlighted specifics of CD79a/CD79b interactions within BCR and related signaling cascades. We have reviewed the complex role of CD79a/CD79b in multiple aspects of normal B cell biology and how is the normal BCR signaling affected by lymphoid neoplasms associated CD79A/CD79B mutations. We have also summarized important unresolved questions and highlighted issues that remain to be explored for better understanding of CD79a/CD79b-mediated signal transduction and the eventual identification of additional therapeutically targetable BCR signaling vulnerabilities.
摘要：
B细胞受体（BCR）是一种B细胞标志表面复合物，可调节正常和恶性B细胞中的多个细胞过程。Igα（CD79a）/Igβ（CD79b）是BCR的重要组成部分，对其功能是必不可少的，信号启动，和信号转导。CD79a/CD79b介导的BCR信号传导是正常以及恶性B细胞通过广泛的信号传导网络存活所必需的。最近的研究确定了这种信号网络的巨大复杂性，并揭示了CD79a/CD79b在信号整合中的新兴作用。在这次审查中,我们专注于CD79a/CD79b的功能特征，总结了CD79a/CD79b翻译后修饰的信号传导后果，并强调了BCR和相关信号级联中CD79a/CD79b相互作用的细节。我们已经回顾了CD79a/CD79b在正常B细胞生物学的多个方面的复杂作用，以及正常BCR信号如何受到淋巴肿瘤相关CD79A/CD79B突变的影响。我们还总结了重要的未解决的问题，并强调了仍有待探索的问题，以更好地理解CD79a/CD79b介导的信号转导并最终鉴定其他治疗可靶向BCR信号传导漏洞。
