PDF(Pubmed)
Abstract：
BACKGROUND: this study aimed to assess the complex relationship between EAT thickness, as measured with echocardiography, and the severity of coronary artery disease (CAD). We investigated whether individuals with higher EAT thickness underwent coronary revascularization. Subsequently, we conducted a three-year follow-up to explore any potential modifications in EAT depots post-angioplasty.
METHODS: we conducted a prospective and retrospective cross-sectional observational study involving 150 patients consecutively referred for acute coronary syndrome, including ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), and unstable angina. Upon admission (T0), all patients underwent coronary angiography to assess the number of pathologic coronary vessels. Percutaneous transluminal coronary angioplasty (PTCA) was performed based on angiogram results if indicated. The sample was categorized into two groups: non-revascularized (no-PTCA) and revascularized (PTCA). Transthoracic echocardiograms to measure epicardial fat thickness were conducted at admission (T0) and after a 3-year follow-up (T1).
CONCLUSIONS: findings revealed a positive correlation between EAT thickness and the severity of coronary artery disease (CAD), with patients undergoing PTCA showing decreased EAT thickness after three years. Echocardiography demonstrated reliability in assessing EAT, offering potential for risk stratification. The study introduces a cut-off value of 0.65 cm as a diagnostic tool for cardiovascular risk. Incorporating EAT measurements into clinical practice may lead to more precise risk stratification and tailored treatment strategies, ultimately reducing the burden of cardiovascular disease.
METHODS: we conducted a prospective and retrospective cross-sectional observational study involving 150 patients consecutively referred for acute coronary syndrome, including ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), and unstable angina. Upon admission (T0), all patients underwent coronary angiography to assess the number of pathologic coronary vessels. Percutaneous transluminal coronary angioplasty (PTCA) was performed based on angiogram results if indicated. The sample was categorized into two groups: non-revascularized (no-PTCA) and revascularized (PTCA). Transthoracic echocardiograms to measure epicardial fat thickness were conducted at admission (T0) and after a 3-year follow-up (T1).
CONCLUSIONS: findings revealed a positive correlation between EAT thickness and the severity of coronary artery disease (CAD), with patients undergoing PTCA showing decreased EAT thickness after three years. Echocardiography demonstrated reliability in assessing EAT, offering potential for risk stratification. The study introduces a cut-off value of 0.65 cm as a diagnostic tool for cardiovascular risk. Incorporating EAT measurements into clinical practice may lead to more precise risk stratification and tailored treatment strategies, ultimately reducing the burden of cardiovascular disease.
摘要：
背景：这项研究旨在评估EAT厚度之间的复杂关系，用超声心动图测量，和冠状动脉疾病（CAD）的严重程度。我们调查了EAT厚度较高的个体是否接受了冠状动脉血运重建。随后，我们进行了为期3年的随访,以探讨血管成形术后EAT储库的任何潜在改变.
方法：我们进行了一项前瞻性和回顾性的横断面观察研究，涉及150名连续转诊为急性冠脉综合征的患者，包括ST段抬高型心肌梗死（STEMI），非ST段抬高型心肌梗死(NSTEMI),和不稳定型心绞痛.入院时（T0），所有患者均接受冠状动脉造影以评估病理冠状动脉血管的数量.经皮腔内冠状动脉成形术（PTCA）根据血管造影结果进行。将样本分为两组:非血管重建(非-PTCA)和血管重建(PTCA)。入院时（T0）和3年随访后（T1）进行经胸超声心动图检查以测量心外膜脂肪厚度。
结论：研究结果表明，EAT厚度与冠状动脉疾病（CAD）的严重程度呈正相关，接受PTCA的患者在三年后显示EAT厚度降低。超声心动图证明了评估EAT的可靠性，提供风险分层的潜力。该研究引入了0.65cm的临界值作为心血管风险的诊断工具。将EAT测量纳入临床实践可能会导致更精确的风险分层和量身定制的治疗策略，最终减轻心血管疾病的负担。
方法：我们进行了一项前瞻性和回顾性的横断面观察研究，涉及150名连续转诊为急性冠脉综合征的患者，包括ST段抬高型心肌梗死（STEMI），非ST段抬高型心肌梗死(NSTEMI),和不稳定型心绞痛.入院时（T0），所有患者均接受冠状动脉造影以评估病理冠状动脉血管的数量.经皮腔内冠状动脉成形术（PTCA）根据血管造影结果进行。将样本分为两组:非血管重建(非-PTCA)和血管重建(PTCA)。入院时（T0）和3年随访后（T1）进行经胸超声心动图检查以测量心外膜脂肪厚度。
结论：研究结果表明，EAT厚度与冠状动脉疾病（CAD）的严重程度呈正相关，接受PTCA的患者在三年后显示EAT厚度降低。超声心动图证明了评估EAT的可靠性，提供风险分层的潜力。该研究引入了0.65cm的临界值作为心血管风险的诊断工具。将EAT测量纳入临床实践可能会导致更精确的风险分层和量身定制的治疗策略，最终减轻心血管疾病的负担。
