PDF(Pubmed)
Abstract：
This review investigates the intricate relationship between hyperparathyroidism (HPT) and thyroid carcinoma (TC), aiming to elucidate their coexistence, potential pathogenetic mechanisms, and clinical implications. A systematic search strategy, employing the MeSH terms \'Hyperparathyroidism\' and \'Thyroid Carcinoma\', spanned publications from 2013 to 2023 across the PubMed, Web of Science, and Scopus databases. Fifteen selected articles were analyzed. Studies unanimously confirm the notable association between primary hyperparathyroidism (PHPT) and thyroid nodules/cancer, with incidences ranging from 2.8% to 47.1%. Key findings reveal a predilection for papillary thyroid carcinoma (PTC) in this association, showcasing varying tumor characteristics and gender disparities. Lower preoperative serum parathyroid hormone (PTH) levels are a potential risk factor for thyroid cancer in PHPT patients. Diverse surgical approaches and tumor characteristics between PHPT and secondary hyperparathyroidism (SHPT) cases were noted. Moreover, this review underscores the scarcity of definitive guidelines in managing concurrent PHPT and thyroid conditions, advocating for comprehensive assessments to enhance diagnostic accuracy and refine therapeutic interventions. Rare coincidental associations, as highlighted by case reports, shed light on unique clinical scenarios. In essence, this review amalgamates evidence to deepen the understanding of the interplay between HPT and TC, emphasizing the need for further research to elucidate underlying mechanisms and guide clinical management.
摘要：
本文综述了甲状旁腺功能亢进（HPT）与甲状腺癌（TC）之间的复杂关系。旨在阐明它们的共存，潜在的致病机制，和临床意义。系统的搜索策略，采用MeSH术语“甲状旁腺功能亢进”和“甲状腺癌”，2013年至2023年跨PubMed的出版物，WebofScience,和Scopus数据库。分析了15篇选定的文章。研究一致证实原发性甲状旁腺功能亢进（PHPT）和甲状腺结节/癌症之间的显著关联，发病率从2.8%到47.1%不等。主要发现揭示了甲状腺乳头状癌（PTC）在这种关联中的优势，展示了不同的肿瘤特征和性别差异。术前血清甲状旁腺激素（PTH）水平较低是PHPT患者甲状腺癌的潜在危险因素。注意到PHPT和继发性甲状旁腺功能亢进（SHPT）病例之间的不同手术方法和肿瘤特征。此外，这篇综述强调了在管理并发PHPT和甲状腺疾病方面缺乏明确的指南，倡导全面评估，以提高诊断准确性和完善治疗干预措施。罕见的巧合协会，正如病例报告所强调的那样，揭示了独特的临床情景。实质上,这篇综述合并了证据，以加深对HPT和TC之间相互作用的理解，强调需要进一步研究以阐明潜在机制并指导临床管理。
