PDF(Pubmed)
Abstract：
CMV infection is still a matter of concern in IBD patients, especially regarding the disease\'s relapse management. Why IBD patients, particularly those affected by ulcerative colitis, are more susceptible to CMV reactivation is not totally explained, although a weakened immune system could be the reason. Various techniques, ranging from serology to histology, can be employed to detect intestinal CMV infection; however, there is currently disagreement in the literature regarding the most effective diagnostic test. Furthermore, CMV involvement in steroid resistance has been broadly discussed, but whether CMV infection is a cause or consequence of the disease severity and, consequently, steroid refractoriness is still debated. Its potential contribution to the lack of response to advanced therapy and small molecules must be more valued and wholly explored. In this review, we look at the actual literature on CMV in IBD patients, and we suggest a pragmatic algorithm for clinical practice management of CMV infection.
摘要：
CMV感染仍然是IBD患者关注的问题，特别是关于疾病的复发管理。为什么IBD患者，特别是那些受溃疡性结肠炎影响的人，更容易被CMV再激活并没有完全解释，尽管免疫系统减弱可能是原因。各种技术,从血清学到组织学，可用于检测肠道CMV感染;然而，目前文献中关于最有效的诊断试验存在分歧.此外，CMV参与类固醇耐药性已被广泛讨论，但是CMV感染是否是疾病严重程度的原因或后果，因此,类固醇难治性仍有争议。必须更加重视和全面探索其对高级疗法和小分子缺乏反应的潜在贡献。在这次审查中,我们看看IBD患者CMV的实际文献，我们提出了一种实用的CMV感染临床实践管理算法。
