Abstract:
The survival rate for pediatric cancer has increased over the past few decades, short- and long-term complications have been detected and studied, and oral complications have emerged as an important topic of research. Here, we aimed to highlight the importance of oral manifestations that may only become apparent years or even decades after cancer treatment. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. We searched articles using PubMed via the MEDLINE, Web of Science, and LILACS databases until October 2023. Overall, 35 observational studies were included, and the results estimated a pooled prevalence of the following dental anomalies: discoloration, 53%; crown-root malformations and agenesis, 36%; enamel hypoplasia, 32%; root development alterations, 29%; unerupted teeth, 24%; microdontia, 16%; hypodontia, 13%; and macrodontia, 7%. Most childhood cancer survivors have at least one dental sequela. Childhood cancer survivors presented a higher risk of having dental alterations than control counterparts. Additional analyses reveal possible sex-based differences that should be explored in future studies. These results collectively highlight the importance of oral healthcare and the prevention of disease in childhood cancer survivors.
摘要:
在过去的几十年里,儿科癌症的存活率有所提高,已发现并研究了短期和长期并发症,口腔并发症已成为一个重要的研究课题。这里,我们旨在强调口腔表现的重要性,这种表现可能在癌症治疗数年甚至数十年后才会变得明显。本系统评价是根据系统评价和荟萃分析的首选报告项目进行的。我们通过MEDLINE使用PubMed搜索文章,WebofScience,和LILACS数据库,直到2023年10月。总的来说,包括35项观察性研究,结果估计了以下牙齿异常的合并患病率:变色,53%;冠根畸形和发育不全,36%;釉质发育不全,32%;根系发育变化,29%;未萌出的牙齿,24%;微型,16%;低度,13%;和宏观,7%。大多数儿童癌症幸存者至少有一个牙齿后遗症。与对照组相比,儿童癌症幸存者患牙齿改变的风险更高。其他分析揭示了可能的性别差异,应该在未来的研究中加以探讨。这些结果共同强调了口腔保健和预防儿童癌症幸存者疾病的重要性。