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Abstract：
The aim of the present study is to report on the ability of metabolic tumor volume (MTV) of liver metastases from pre-transplant 18F-FDG PET/CT in combination with conventional radiological measurements from CT scans to predict long-term disease-free survival (DFS), overall survival (OS), and survival after relapse (SAR) after liver transplantation for colorectal liver metastases. The total liver MTV was obtained from the 18F-FDG PET/CT, and the size of the largest metastasis and the total number of metastases were obtained from the CT. DFS, OS, and SAR for patients with a low and high MTV, in combination with a low and high size, number, and tumor burden score, were compared using the Kaplan-Meier method and log-rank test. Patients with a low number of metastases and low MTV had a significantly longer OS than those with a high MTV, with a median survival of 151 vs. 26 months (p = 0.010). Patients with a high number of metastases and low MTV had significantly longer DFS, OS, and SAR than patients with a high MTV (p = 0.034, 0.006, and 0.026). The tumor burden score of group/zone 3, in combination with a low MTV, had a significantly improved DFS, OS, and SAR compared to those with a high MTV (p = 0.034, <0.001, and 0.006). Patients with a low MTV of liver metastases had a long DFS, OS, and SAR despite a high number of liver metastases and a high tumor burden score.
摘要：
本研究的目的是报告移植前18F-FDGPET/CT的肝转移代谢肿瘤体积（MTV）与CT扫描的常规放射学测量相结合的能力，以预测长期无病生存（DFS）。总生存期（OS），和复发后生存（SAR）肝移植后的结直肠肝转移。从18F-FDGPET/CT获得总肝MTV，从CT获得最大转移的大小和转移的总数。DFS,操作系统,和SAR为低和高MTV的患者，结合低尺寸和高尺寸，number,和肿瘤负荷评分，使用Kaplan-Meier方法和对数秩检验进行比较。转移数低和MTV低的患者的OS明显长于MTV高的患者,中位生存期为151vs.26个月（p=0.010）。具有高数量转移和低MTV的患者有明显更长的DFS,操作系统,和SAR高于MTV高的患者（p=0.034、0.006和0.026）。组/区3的肿瘤负荷评分，结合低MTV，有一个显著改善的DFS，操作系统,与高MTV的SAR相比（p=0.034，<0.001和0.006）。肝转移MTV较低的患者DFS较长，操作系统,尽管有大量的肝转移和高肿瘤负荷评分，但SAR。
