PDF(Pubmed)
Abstract：
This study aimed to investigate the relationship between rosacea and headaches, focusing on different subtypes, as well as the associated clinical features and triggering factors. In this prospective study, 300 patients diagnosed with rosacea and 320 control subjects without rosacea or any connected mast cell activation illness were included. Patients with rosacea were assessed by a dermatologist according to the 2019 updated rosacea classification (ROSCO panel). Accordingly, patients were classified based on their predominant rosacea subtype as follows: erythematotelangiectatic (ETR), papulopustular (PPR), or phymatous (RhR). Patients experiencing headaches were assessed using the International Headache Classification. Headaches were categorized as migraine, tension-type headaches (TTHs), secondary types (STHs), and cluster-type headaches (CTHs). The ratio of headache was 30.3% in the rosacea group, which did not show a significant difference compared to the control group (30.3% vs. 25.0%, p = 0.138). In 81.3% of rosacea patients with headaches, headache onset occurred after the diagnosis of rosacea. The rate of patients with headaches was higher in the ETR group compared to the PPR and RhR groups (35.2% vs. 16.2% vs. 23.1%, p = 0.007, respectively). In terms of headache subtypes, the rates of patients with migraine and STHs were higher in the ETR group compared to the PPR and RhR groups, while the rate of patients with TTHs was higher in the RhR group. A positive correlation was found between rosacea severity and migraine severity (r = 0.284, p < 0.05). Among the triggering factors for rosacea, only sunlight was found to be associated with headaches. Lower age, female gender, and moderate to severe rosacea severity were identified as independent factors increasing the likelihood of headaches. A significant portion of rosacea patients experience headaches. Particularly, different subtypes of rosacea may be associated with various types of headaches. This study, highlighting the connection between migraine and ETR, is a pioneering work that demonstrates common pathogenic mechanisms and potential triggers.
摘要：
本研究旨在探讨酒渣鼻与头痛的关系,专注于不同的亚型，以及相关的临床特征和触发因素。在这项前瞻性研究中，包括300名诊断为酒渣鼻的患者和320名没有酒渣鼻或任何相关的肥大细胞活化疾病的对照受试者。皮肤科医生根据2019年更新的酒渣鼻分类（ROSCO面板）评估酒渣鼻患者。因此，患者根据其主要的酒渣鼻亚型分类如下：丘疹脓疱（PPR），或植物（RhR）。使用国际头痛分类对经历头痛的患者进行评估。头痛被归类为偏头痛，紧张型头痛（TTH），次要类型(STHs)，和丛集型头痛（CTHs）。酒渣鼻组的头痛率为30.3%,与对照组相比，没有显着差异(30.3%vs.25.0%,p=0.138）。在81.3%有头痛的酒渣鼻患者中,头痛发生在酒渣鼻诊断后。与PPR和RhR组相比，ETR组的头痛患者发生率更高（35.2％vs.16.2%vs.23.1%,分别为p=0.007)。就头痛亚型而言，与PPR和RhR组相比，ETR组中偏头痛和STHs的发生率更高，而RhR组患者的TTHs发生率较高。酒渣鼻严重程度与偏头痛严重程度呈正相关（r=0.284，p<0.05）。在酒渣鼻的触发因素中，只有阳光被发现与头痛有关。年龄较低,女性性别,和中度至重度酒渣鼻严重程度被确定为增加头痛可能性的独立因素。酒渣鼻患者的很大一部分经历头痛。特别是,不同亚型的酒渣鼻可能与各种类型的头痛有关。这项研究,强调偏头痛和ETR之间的联系，是一项开创性的工作，证明了常见的致病机制和潜在的触发因素。
