PDF(Pubmed)
Abstract：
Biological activity and bioactive compound content in sea cucumbers was assessed, considering Parastichopus regalis, Holothuria mammata, Holothuria forskali, and Holothuria arguinensis as species and intestine, muscle band, respiratory tree, body wall, and gonads as tissues. P. regalis had the lowest content in phenolic compounds and antioxidant activity in contrast to Holothuria species. In the respiratory tree, the highest phenolic concentration was recorded in H. arguinensis, 76.4 ± 1.2 mg GAE/100 g dw vs. 21.0-49.0 mg GAE/100 g dw in the other species. H. arguinensis had the highest DPPH and FRAP results in the gonads, 13.6 ± 0.7 mg AAE/100 g dw vs. 2.6-3.5 mg AAE/100 g dw and 27.1 ± 0.3 μmol Fe2+/g dw vs. 8.0-15.9 μmol Fe2+/g dw, respectively. Overall, P. regalis biomass presented the highest anti-inflammatory activity levels and H. arguinensis the lowest anti-inflammatory levels. The respiratory tree was the most anti-inflammatory (measured by the inhibition of cyclooxygenase-2, COX-2) tissue in H. mammata and H. forskali (also the muscle band in this case), 76.3 ± 6.3% and 59.5 ± 3.6% COX-2 inhibition in 1 mg/mL aqueous extracts, respectively. The results demonstrated a variable bioactive potential and advantage in targeting antioxidant properties in the muscle band and anti-inflammatory activity in the respiratory tree, which may constitute a starting point for a biorefinery approach envisaging multiple applications.
摘要：
海参的生物活性和生物活性化合物含量进行了评估，考虑到Parastichopusregalis,Holothuriamammata，Holothuriaforskali,和海藻作为物种和肠道，肌肉带,呼吸树,体壁,和性腺作为组织。与Holothuria物种相比，regalis的酚类化合物含量和抗氧化活性最低。在呼吸树上，最高的酚类浓度记录在阿根廷。76.4±1.2mgGAE/100gdwvs.其他物种为21.0-49.0mgGAE/100gdw。H.arguinensis在性腺中的DPPH和FRAP结果最高，13.6±0.7mgAAE/100gdwvs.2.6-3.5mgAAE/100gdw和27.1±0.3μmolFe2+/gdw与8.0-15.9μmolFe2+/gdw,分别。总的来说,regalis生物量表现出最高的抗炎活性水平，而arguinensis表现出最低的抗炎水平。在H.mammata和H.forskali（在这种情况下也是肌肉带）中，呼吸树是最抗炎的（通过抑制环氧合酶2，COX-2来测量）组织，76.3±6.3％和59.5±3.6％COX-2在1mg/mL水提物中的抑制作用，分别。结果表明，在针对肌肉束中的抗氧化特性和呼吸树的抗炎活性方面具有可变的生物活性潜力和优势，这可以构成设想多种应用的生物炼制方法的起点。
