PDF(Pubmed)
Abstract：
Bovine cysticercosis is categorized as a serious parasitic zoonotic infestation. The infection is mainly caused by the tapeworm Taenia saginata, which infects cattle and humans. The larval stage, Cysticercus bovis (C. bovis), is found in the skeletal and cardiac muscles of infected cattle. Despite its potential public health concern, few studies have been conducted on cardiac cysticercosis in Upper Egypt. This study investigates the prevalence, epidemiology, and impact of cardiac cysticercosis in Upper Egypt, emphasizing how histopathological changes in cardiac muscle and physiological parameters might be associated with the infection. From December 2022 to October 2023, a total of 941 animals from Assiut province, Upper Egypt, were slaughtered and their cardiac muscles were examined for the presence of C. bovis. Cysts were classified as viable or degenerated through macroscopic inspection. The overall prevalence of C. bovis infected hearts made up 10.8% of the total examined. The highest prevalence rate was in the summer season followed by spring; winter had the lowest infections. The histopathological examination of infected tissues revealed immune cell infiltration around Cysticercus-infected areas. Additionally, Bax immunostaining demonstrated the apoptotic effect of cysticercosis. Regarding the measured physiological parameters, there were non-significant changes in plasma levels of total protein and albumin in cattle infected with cysticercosis compared with control animals. Moreover, there was a significant decrease in total antioxidant capacity (TAC) combined with a significant increase in lipid peroxide (Malondialdehyde) (MDA), troponin T, and lactate dehydrogenase (LDH) activity in infected animals. The present work documented a set of epidemiological and pathological findings, revealing that C. bovis is a potentially harmful parasite and can cause significant health problems in both cattle and humans.
摘要：
牛囊虫病被归类为严重的人畜共患寄生虫。感染主要是由带虫带囊,感染牛和人类。幼虫阶段，牛囊尾蚴(C.bovis),在受感染牛的骨骼肌和心肌中发现。尽管其潜在的公共卫生问题，在上埃及，很少有关于心脏囊虫病的研究。这项研究调查了患病率，流行病学,以及上埃及心脏囊虫病的影响，强调心肌和生理参数的组织病理学变化可能与感染有关。从2022年12月到2023年10月，来自Assiut省的941只动物，上埃及,被屠宰，并检查它们的心肌是否存在牛梭菌。通过宏观检查将囊肿分类为有活力的或退化的。牛梭菌感染的心脏的总体患病率占检查总数的10.8%。患病率最高的是夏季，其次是春季；冬季的感染率最低。感染组织的组织病理学检查显示，囊尾蚴感染区域周围有免疫细胞浸润。此外,Bax免疫染色证明了囊虫病的凋亡作用。关于测量的生理参数，与对照动物相比，感染囊虫病的牛的血浆总蛋白和白蛋白水平无明显变化。此外，总抗氧化能力（TAC）显着下降，脂质过氧化物（丙二醛）（MDA）显着增加，肌钙蛋白T,和感染动物的乳酸脱氢酶（LDH）活性。目前的工作记录了一组流行病学和病理学发现，表明C.bovis是一种潜在的有害寄生虫，可以在牛和人类中引起严重的健康问题。
