Abstract：
The timely suppression of inflammatory mediator production and mitigation of their effects on pancreatic acinar cells are crucial for the successful management of acute pancreatitis. To achieve effective treatment, we present a novel approach utilizing cysteine modified PEG nanoparticles for both precise accumulation at the site of pancreatitis and specific targeting of acinar cells. Methylprednisolone, a nonsteroidal anti-inflammatory drug, was tailored to enhance its circulation time in the bloodstream, preferentially accumulate in the pancreas and enhance cell uptake efficiency by acinar cells through specifically targeting L-Type amino acid transporter 1. The nanosystem significantly downregulated pro-inflammatory cytokines in plasma, resulting in the effective suppression of inflammation in acinar cells within an acute pancreatitis rat model. The utilization of the dual targeted therapy strategy holds considerable potential for the clinical management of pancreatitis.
摘要：
及时抑制炎症介质的产生并减轻其对胰腺腺泡细胞的影响对于成功治疗急性胰腺炎至关重要。为了实现有效的治疗，我们提出了一种利用半胱氨酸修饰的PEG纳米颗粒在胰腺炎部位的精确积累和腺泡细胞的特异性靶向的新方法.甲基强的松龙,一种非甾体抗炎药,是为了增加它在血液中的循环时间而定制的，通过特异性靶向L型氨基酸转运蛋白1，优先在胰腺中积累并提高腺泡细胞的细胞摄取效率。纳米系统显著下调血浆中的促炎细胞因子，从而有效抑制急性胰腺炎大鼠模型中腺泡细胞的炎症。双重靶向治疗策略的利用对于胰腺炎的临床管理具有相当大的潜力。
