PDF(Pubmed)
Abstract：
BACKGROUND: Dermal Regeneration Templates may be used in the reconstruction of large skin defects after cutaneous malignancy excisions. Bowen\'s disease (BD; squamous cell carcinoma in situ) is a common and persistent condition that can be related to chronic sun damage, and consequently, is usually located on the head and neck area or on the lower limbs. Literature does not provide clear guidelines on the treatment of BD, limiting itself to describing a wide range of different methods that can be used, including surgery, laser therapy or topical options. However, large lesions tend to scar in the post-operative setting and hence are difficult to treat surgically.
METHODS: In this paper the authors present a case of a male in his 60s, ASA III score, who presented with a history of histopathologically-confirmed squamocellular carcinoma in the neck and supraclavicular region. Due to recurrent carcinomas the patient was treated with an extensive skin excision and a successful reconstruction using a Dermal Regeneration Template. The work has been reported in line with the SCARE criteria.
CONCLUSIONS: The main surgical problem caused by BD is reaching complete oncological resection and, consequently, the need for extensive skin excisions.
CONCLUSIONS: The use of the skin substitute resulted in a satisfactory functional and aesthetic result, with total clearance and no recurrence observed after 16 months.
METHODS: In this paper the authors present a case of a male in his 60s, ASA III score, who presented with a history of histopathologically-confirmed squamocellular carcinoma in the neck and supraclavicular region. Due to recurrent carcinomas the patient was treated with an extensive skin excision and a successful reconstruction using a Dermal Regeneration Template. The work has been reported in line with the SCARE criteria.
CONCLUSIONS: The main surgical problem caused by BD is reaching complete oncological resection and, consequently, the need for extensive skin excisions.
CONCLUSIONS: The use of the skin substitute resulted in a satisfactory functional and aesthetic result, with total clearance and no recurrence observed after 16 months.
摘要：
背景：皮肤再生模板可用于皮肤恶性肿瘤切除后大面积皮肤缺损的重建。Bowen病(BD;鳞状细胞原位癌)是一种常见和持续的疾病，可能与慢性阳光损伤有关。因此，通常位于头部和颈部区域或下肢。文献没有提供关于BD治疗的明确指南，仅限于描述可以使用的各种不同方法，包括手术,激光治疗或局部选择。然而,大的病变在手术后容易形成疤痕，因此难以手术治疗。
方法：在本文中，作者介绍了一个60多岁的男性案例，ASAIII得分，有组织病理学证实的颈部和锁骨上区域鳞状细胞癌病史的患者。由于复发性癌症，该患者接受了广泛的皮肤切除术并使用皮肤再生模板成功进行了重建。报告的工作符合SCARE标准。
结论：由BD引起的主要手术问题是达到完全肿瘤切除，因此,需要广泛的皮肤切除。
结论：使用皮肤替代品可获得令人满意的功能和美学效果，完全清除，16个月后无复发。
方法：在本文中，作者介绍了一个60多岁的男性案例，ASAIII得分，有组织病理学证实的颈部和锁骨上区域鳞状细胞癌病史的患者。由于复发性癌症，该患者接受了广泛的皮肤切除术并使用皮肤再生模板成功进行了重建。报告的工作符合SCARE标准。
结论：由BD引起的主要手术问题是达到完全肿瘤切除，因此,需要广泛的皮肤切除。
结论：使用皮肤替代品可获得令人满意的功能和美学效果，完全清除，16个月后无复发。
