Abstract：
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common hormonal disorder among young women, correlated with hyperandrogenism. Among the symptoms of PCOS, vocal alterations are quite unknown. Dysphonia may be related to hyperandrogenism, and there is no consensus about its prevalence and the severity of vocal disorders, which can cause noticeable discomfort.
METHODS: A systematic review of the literature was conducted. Four studies on PCOS that evaluated the phonatory system were included for a total of 174 patients (96 PCOS, 78 controls), and a meta-analysis on comparable data was performed.
RESULTS: Four studies evaluated parameters related to vocal symptomatology, altered audiometric examination, and findings at the laryngoscopy in patients affected by PCOS versus controls. Although the individual studies showed increased incidence of alterations and a tendency to develop speech fatigue in women with PCOS, when the results of studies were pulled in meta-analysis, the overall difference was not statistically significant. The studies themselves were very different from each other; therefore, it is hard to draw any firm conclusions.
CONCLUSIONS: The aim of this study was to assess the prevalence of vocal alterations, the correlation with hyperandrogenism, the quality of life, and the voice changes after starting a therapy for PCOS. The present meta-analysis failed to find any difference in terms of PCOS and control cohort. However, the lack of high-quality studies makes it difficult to draw firm conclusions. New and larger studies or big population program data are therefore warranted.
METHODS: A systematic review of the literature was conducted. Four studies on PCOS that evaluated the phonatory system were included for a total of 174 patients (96 PCOS, 78 controls), and a meta-analysis on comparable data was performed.
RESULTS: Four studies evaluated parameters related to vocal symptomatology, altered audiometric examination, and findings at the laryngoscopy in patients affected by PCOS versus controls. Although the individual studies showed increased incidence of alterations and a tendency to develop speech fatigue in women with PCOS, when the results of studies were pulled in meta-analysis, the overall difference was not statistically significant. The studies themselves were very different from each other; therefore, it is hard to draw any firm conclusions.
CONCLUSIONS: The aim of this study was to assess the prevalence of vocal alterations, the correlation with hyperandrogenism, the quality of life, and the voice changes after starting a therapy for PCOS. The present meta-analysis failed to find any difference in terms of PCOS and control cohort. However, the lack of high-quality studies makes it difficult to draw firm conclusions. New and larger studies or big population program data are therefore warranted.
摘要：
背景：多囊卵巢综合征（PCOS）是年轻女性中常见的激素紊乱，与高雄激素血症相关。在PCOS的症状中，声音的改变是未知的。发声障碍可能与高雄激素血症有关,关于其患病率和声乐障碍的严重程度没有达成共识，这会引起明显的不适。
方法：对文献进行系统综述。包括四项评估发声系统的PCOS研究，总共174名患者(96名PCOS，78个对照），并对可比数据进行了荟萃分析。
结果：四项研究评估了与声带症状学有关的参数，改变的听力检查，与对照组相比，受PCOS影响的患者在喉镜检查中的发现。虽然个别研究显示，多囊卵巢综合征女性的改变发生率和言语疲劳倾向增加，当将研究结果进行元分析时，总体差异无统计学意义。这些研究本身非常不同，因此，很难得出任何坚定的结论。
结论：本研究的目的是评估声带改变的患病率，与高雄激素血症的相关性，生活质量,开始治疗PCOS后声音也会发生变化.目前的荟萃分析未能发现PCOS和对照组的任何差异。然而,缺乏高质量的研究使得很难得出确切的结论。因此，有必要进行新的和更大的研究或大型人口计划数据。
方法：对文献进行系统综述。包括四项评估发声系统的PCOS研究，总共174名患者(96名PCOS，78个对照），并对可比数据进行了荟萃分析。
结果：四项研究评估了与声带症状学有关的参数，改变的听力检查，与对照组相比，受PCOS影响的患者在喉镜检查中的发现。虽然个别研究显示，多囊卵巢综合征女性的改变发生率和言语疲劳倾向增加，当将研究结果进行元分析时，总体差异无统计学意义。这些研究本身非常不同，因此，很难得出任何坚定的结论。
结论：本研究的目的是评估声带改变的患病率，与高雄激素血症的相关性，生活质量,开始治疗PCOS后声音也会发生变化.目前的荟萃分析未能发现PCOS和对照组的任何差异。然而,缺乏高质量的研究使得很难得出确切的结论。因此，有必要进行新的和更大的研究或大型人口计划数据。
